en pharmacology pharmacology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN">Type 2 diabetes or non-insulin-dependent diabetes is one of the most common types of diabetes. The existing treatments for type 2 diabetes have not been able to completely cure this disease in affected cases.&nbsp; Sumac showed antioxidants, reducing blood sugar and serum cholesterol levels. In this study, according to the positive effects of sumac in diabetic diseases, it was tried that sumac capsules were prepared from the aqueous extract of this plant, and its effect on the factors of diabetes in patients was evaluated.</span></span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> This double-blind randomized controlled clinical trial was conducted on sixty type 2diabetic volunteers. <span lang="EN">The volunteers were divided into two groups, control, and sumac supplement groups.</span> Baseline venous blood samples were collected after overnight fasting before intervention and a second sampling was done in the 12th week. Hb1AC, FBS, TG, TC, LDL-C, and HDL-C were measured via commercial kits.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> FBS, HDL-C, and HbA1C measured in the sumac supplement group were significantly different (p<0.01) compared to the control group and baseline of the study. Moreover, there is no significant difference in levels of the sumac supplement group (CHOL, LDL-C, and TG) compared to the control group and baseline of the study (p>0.05).<b><span lang="EN" style="font-size:10.0pt"></span></b></span><br> <b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> Our data confirmed the anti-diabetic effect of sumac in patients.&nbsp; Because of sumac safety, it seems that sumac capsules can be used for the treatment of diabetic patients along with routine chemical drugs</span></span> Sumac, Rhus coriaria L., Diabetes, Clinical trial 417 423 http://caspjim.com/browse.php?a_code=A-10-3353-1&slc_lang=en&sid=1 Hossein Asgarirad dr_asgarirad@yahoo.com 100319475328460053261 100319475328460053261 No Department of Pharmaceutics, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. Soleiman Mahjoub smahjoub20@gmail.com 100319475328460053262 100319475328460053262 No Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Mohsen yadollahi mohsen.21501@yahoo.com 100319475328460053263 100319475328460053263 Yes Department of Food Hygiene and Quality Control, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran. Siamak Navaee Siamaknavaee@gmail.com 100319475328460053264 100319475328460053264 No Graduated from General Medicine, Kerman University of Medical Sciences, Kerman, Iran Shervin Amirkhanloo shervin.amirkhanloo@gmail.com 100319475328460053265 100319475328460053265 No Ph.D Student in Pharmaceutics, Student Research Committee, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran. AliSina shohreh As.shohreh@gmail.com 100319475328460053266 100319475328460053266 No Graduated in Pathology, Shahid Beheshti University of Medical Sciences, Tehran, Iran