en Cardiology Cardiology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Glycated hemoglobin A1c (HbA1c) level is related to increased cardiovascular diseases (CVDs) and death, even in non-diabetic subjects. Although in ST-elevation myocardial infarction (STEMI) cases, the association between HbA1c and coronary artery disease (CAD) remains unclear. </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> This cross-sectional study was conducted on 167 non-diabetic STEMI patients undergoing primary percutaneous coronary intervention (PCI). The SYNTAX score was utilized to evaluate CAD severity. Cases were categorized into three groups based on the HbA1c levels: <5%, 5.1-5.9%, and 6-6.5%. </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> SYNTAX scores significantly increased in the cases with 6 to 6.5 HbA1c levels compared to the other group (28.9&plusmn;9.5 vs 21.2&plusmn;5.2 vs 13.7&plusmn;4.5, P=0.000). Additionally, death was more elevated in this group (4% vs 0% vs 0%, P=0.006). </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i>&nbsp;Higher HbA1c levels are strongly associated with coronary atherosclerosis in non-diabetic patients that present with non-diabetic STEMI. Consequently, in non-diabetic STEMI patients, HbA1c may be able to predict the severity of CAD.</span></span></span><br> &nbsp; Coronary SYNTAX Score, HbA1c, Non-Diabetic, Myocardial Infarction 519 524 http://caspjim.com/browse.php?a_code=A-10-2529-8&slc_lang=en&sid=1 Majid Saraei koushki Majidsaraie2024@gmail.com 100319475328460053345 100319475328460053345 No Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Razieh parizad r_parizad2003@yahho.com 100319475328460053346 100319475328460053346 No Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Ali Abdollahzadeh a.abdollahzadh@gmail.com 100319475328460053347 100319475328460053347 No Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran Ahmad Separham separham@gmail.com 100319475328460053348 100319475328460053348 Yes Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran