en Traditional Medicine Review Article Review Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="color:#0033ff;"><span style="line-height:150%"><em><b><span style="background:#fafafa"><span style="line-height:150%">Background:</span></span></b></em></span></span><span style="color:#000000;"><span style="line-height:150%"> <span style="line-height:150%">Musculoskeletal pain is a common and bothersome condition influencing a large segment of the population. It can significantly impact individuals&#39; quality of life and limit daily activities. Traditionally, chamomile (Matricaria chamomilla) has been used for its pain-relieving properties. This systematic review and meta-analysis aimed to investigate the efficacy of chamomile in reducing musculoskeletal pain. </span></span></span><br> <span style="color:#0033ff;"><span style="line-height:150%"><em><b><span style="background:#fafafa"><span style="line-height:150%">Methods:</span></span></b></em></span></span><span style="color:#000000;"><span style="line-height:150%"> <span style="line-height:150%">We searched English language databases including Cochrane, Scopus, PubMed, Web of Science, and Google Scholar for published studies up to July 2024. Studies examining chamomile&#39;s influence on musculoskeletal discomfort in humans were included. In-vitro, animal, and observational studies were excluded. </span></span></span><br> <span style="color:#0033ff;"><span style="line-height:150%"><em><b><span style="background:#fafafa"><span style="line-height:150%">Results</span></span><span style="line-height:150%">:</span></b></em></span></span><span style="color:#000000;"><span style="line-height:150%"><span style="line-height:150%"> A total of eight studies were analyzed. The findings suggest a potential analgesic effect of chamomile compared to placebo. Additionally, no significant difference was found between chamomile and other pain medication.<span style="background:white"> The studies included in this review, however, exhibited significant heterogeneity.</span></span></span></span><br> <span style="color:#0033ff;"><span style="line-height:150%"><em><b><span style="background:white"><span style="line-height:150%">Conclusion:</span></span></b></em></span></span><span style="color:#000000;"><span style="line-height:150%"> <span style="line-height:150%">Chamomile may be a promising alternative for pain management due to its potential analgesic effect and lack of significant difference compared to other pain medication; however, more research is needed.</span><span style="line-height:150%"></span></span></span></span></span><br> &nbsp; Chamomile, VAS, Musculoskeletal pain, Clinical Trial, Meta-analysis 630 640 http://caspjim.com/browse.php?a_code=A-10-3512-1&slc_lang=en&sid=1 Mostafa Ahmadi mostafa.ahmadi.amol@gmail.com 100319475328460054583 100319475328460054583 No Student Research Committee Seyed ali Mozaffarpur seyyedali1357@gmail.com 100319475328460054584 100319475328460054584 No Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute Hoda Shirafkan hodashirafkan@gmail.com 100319475328460054585 100319475328460054585 Yes social determeninace of health research, institute