en Cardiology Cardiology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:13.8pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN-CA">The relationship between epicardial fat and coronary stenosis has been a topic of recent discussion. This study aimed to determine the correlation between epicardial fat volume and coronary artery stenosis in patients undergoing CT angiography. </span></span><br> <span style="line-height:13.8pt"><b><i><span style="color:blue">Methods:</span></i></b> <span lang="EN-CA">In this descriptive/cross-sectional study, 240 patients with low to moderate risk of CAD, referred to the CT angiography unit of Farshchian Hospital in Hamadan in 2023, were selected via the Census method. Coronary artery stenosis was assessed using a 128-slice multi-detector CT scan, while epicardial fat volume was measured using CT scan analysis. Statistical analyses were performed using SPSS software Version 21, with a significance level set at 0.05. </span></span><br> <span style="line-height:13.8pt"><b><i><span style="color:blue">Results:</span></i></b> <span lang="EN-CA">The mean age of the patients was 54.69 years, with 52.5% being males. The mean epicardial fat volume was 76.64 ml, and 58.3% of the patients had coronary artery stenosis. The mean epicardial fat volume in patients with coronary stenosis was 82.82&plusmn;31.41 ml, compared to 65.66&plusmn;25.79 ml in those without stenosis (p<0.001). There was a significant positive correlation between epicardial fat volume and patients&#39; age, calcium score, vessel score, and LDL levels. Additionally, the mean epicardial fat volume in patients with both obstructive and non-obstructive stenosis in the LAD and LCX was significantly higher than in vessels without stenosis (P < 0.05). </span></span><br> <span style="line-height:13.8pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> <span lang="EN-CA">Epicardial fat volume is significantly associated with coronary artery stenosis and calcium score. Therefore, it can be utilized to determine and predict the presence and severity of coronary artery stenosis.</span></span></span></span><br> &nbsp; Coronary arteries, CT angiography, Epicardial fat, Stenosis 767 774 http://caspjim.com/browse.php?a_code=A-10-3323-2&slc_lang=en&sid=1 Seyed Kianoosh Hosseini k.hoseini@umsha.ac.ir 100319475328460054676 100319475328460054676 No Department of Cardiology, School of Medicine, Farshchian Cardiovascular Subspecialty Medical Center, Hamadan University of Medical Sciences, Hamadan, Iran. Ghulam Muhammad Rind Baloch nairesearchgroup@gmail.com 100319475328460054677 0009-0007-4950-9835 No Department of Radiology, School of Medicine, Farshchian Cardiovascular Subspecialty Medical Center, Hamadan University of Medical Sciences, Hamadan, Iran. Ali Fathi Jouzdani ali.fathi77@gmail.com 100319475328460054678 100319475328460054678 Yes USERN Office, Hamadan University of Medical Sciences, Hamadan, Iran. Mohammad Ali Seif Rabiei Seifrabie@umsha.ac.ir 100319475328460054679 100319475328460054679 No Department of Community Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. Seyed Kamaledin Hadei km.hadei@gmail.com 100319475328460054680 100319475328460054680 No Department of Radiology, School of Medicine, Farshchian Cardiovascular Subspecialty Medical Center, Hamadan University of Medical Sciences, Hamadan, Iran.