en Anesthesiology Anesthesiology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background</span></i></b><i><span style="color:blue">:</span></i> Hypotension after spinal anesthesia is a serious complication during cesarean sections, potentially reducing maternal cardiac output and placental blood flow, affecting both mother and baby. This study aimed to compare the effects of norepinephrine and phenylephrine on maternal hemodynamic changes following spinal anesthesia in elective cesarean surgeries.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> In this clinical trial study, 52 pregnant mothers&rsquo; candidates for elective cesarean surgery were divided into two groups. After spinal anesthesia, the norepinephrine group received a 10-microgram bolus of norepinephrine, while the phenylephrine group received 100 micrograms of phenylephrine. The primary outcomes included blood pressure, heart rate, and measurement time. These were recorded three times before the start of spinal anesthesia, immediately after, and every 3 minutes until discharge, and then twice at 3-minute intervals after childbirth.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> Mean arterial pressure in norepinephrine group was always higher than phenylephrine. Their difference was significant at the ninth minute (p<0.001) and the twelfth minute (P=0.009). Diastolic pressure in the two studied groups was significant at the ninth minute (p<0.001). 2 patients in norepinephrine group (7.6%) and 6 (23%)patients in phenylephrine group needed vasopressor. 3.8% of patients in norepinephrine group and 34% of patients in phenylephrine group had bradycardia (P=0.020).</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion</span></i></b><i><span style="color:blue">:</span></i> This study shows that norepinephrine is as effective as phenylephrine in preventing blood pressure drop in patients undergoing cesarean section, but it does not cause bradycardia.</span></span></span><br> &nbsp; Norepinephrine, phenylephrine, spinal anesthesia, cesarean surgery 67 73 http://caspjim.com/browse.php?a_code=A-10-3551-1&slc_lang=en&sid=1 Nadia Banihashem nbanihashem@yahoo.com 100319475328460055759 100319475328460055759 No Department of Anesthesiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran Milad Minagar dr.minagar@live.com 100319475328460055760 100319475328460055760 Yes Department of Anesthesiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran Hoda Shirafkan hodashirafkan@gmail.com 100319475328460055761 100319475328460055761 No Traditional Medicine and History of Medical Sciences Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Farhad Norollahi f.nurollahi@gmail.com 100319475328460055762 100319475328460055762 No Department of Anesthesiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran