en Oncology Oncology Short Communication Short Communication <br> <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b><b> </b>Cancers of the brain and central nervous system, with more than 250,000 deaths in 2020 and an age-adjusted mortality rate of 3.05 per 100,000, rank twelfth in mortality among various cancers.&nbsp; Our study aimed to investigate the crude rate, age-standardized mortality rate (ASMR) and the trends of brain and CNS malignancies over nine years in northern Iran.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> This cross-sectional study conducted a thorough analysis of mortality caused by brain and CNS cancers in Babol between the years 2013 and 2021. Death registration and classification systems at Babol University of Medical Sciences were used to collect the cause-of-death data. A census sampling method was used to determine the number of brain and CNS cancers deaths. All analyses were done using SPSS Version 22 and STATA Version 14. The significance level was set at (p<0.05). The crude and age-standardized mortality rate was calculated. The Cochran-Armitage Trend Test was utilized to determine the mortality trend. </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> The crude rates and ASMRs for brain and CNS cancers increased, from 3.3 and 3.2 per 100,000 people in 2013 to 7.0 and 6.3 per 100,000 in 2021, respectively (p < 0.001). Additionally, over the nine years, an increasing trend was explicitly observed for brain cancer (p < 0.001), while the trends for other cancers remained stable.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion:</span></i></b> The ASMR and the trend of brain and CNS cancers are on the rise. This study&#39;s findings could be beneficial for designing monitoring programs and investigating cancer risk factors.</span></span></span><br> &nbsp; Brain Neoplasms, Central Nervous System, Iran, Mortality, Meningeal Neoplasms 791 796 http://caspjim.com/browse.php?a_code=A-10-3555-1&slc_lang=en&sid=1 Mohsen Karami karami158@yahoo.com 100319475328460054686 100319475328460054686 No Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Department of Parasitology and Mycology, Babol University of Medical Sciences, Babol, Iran. Amir-Hossein Lashkarbolouki myamirhl1394@gmail.com 100319475328460054687 0009-0001-6218-8489 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran Pouyan Ebrahimi pouyanebi1375@gmail.com 100319475328460054688 100319475328460054688 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran Seyed-Hossein Hosseini-Berneti Kondes1371@yahoo.com 100319475328460054689 0009-0003-7122-9873 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran Mohammad-Amin Ghezel mohammadaminghezel7@gmail.com 100319475328460054690 0009-0005-5306-7377 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran Hossein-Ali Nikbakht hosseinali.nikbakht@gmail.com 100319475328460054691 100319475328460054691 Yes Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.