en Neurology Neurology Review Article Review Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:150%"><span style="color:#0033ff;"><em><b><span style="line-height:150%">Background:</span></b></em></span><span style="line-height:150%"> Celiac disease (CD) is an autoimmune disease with gluten intolerance, which is associated with various neurological disorders. Patients may present with signs of malabsorption or extraintestinal involvement or be completely asymptomatic. It is usually unknown how common celiac disease is in migraine patients. Therefore, the purpose of this study was to investigate the prevalence of CD in migraine patients using a systematic review and meta-analysis.</span></span><br> <span style="line-height:150%"><span style="color:#0033ff;"><em><b><span style="line-height:150%">Methods:</span></b></em></span><span style="line-height:150%"> PRISMA guidelines created a framework for the construction of this review article. Two researchers examined databases such as Scopus, PubMed, Web of Science, and Google Scholar to review the literature, with no limitations on time until May 2024. The Cochran&#39;s test and the I² index were used for evaluation. The heterogeneity of data studies was analyzed using Stata14.2 software, and p<0.05 was considered significant.</span></span><br> <span style="line-height:150%"><span style="color:#0033ff;"><em><b><span style="line-height:150%">Results:</span></b></em></span><span style="line-height:150%"> A total of 6 articles including 14526 migraine patients were comprised in the meta-analysis. The overall prevalence of CD in migraine patients was estimated to be (2% (95% CI: 0%-5%, I²=75.37, P=0.001)). Also, the Odds of CD disease in migraine patients compared to non-migraine patients was estimated to be equal (2.20 (95% CI: 0.87-5.54, I2=48.4, P=0.121)). Additionally, the majority of the research was conducted in Europe.</span></span><br> <span style="line-height:150%"><span style="color:#0033ff;"><em><b><span style="line-height:150%">Conclusions:</span></b></em></span><span style="line-height:150%"><span style="color:#0033ff;"><em> </em></span>Although the small amount of research accomplished in this particular situation, our data indicate a relatively low prevalence of CD in migraine patients. Therefore, more frequent and thorough research in this field is advised. Patients with migraines experienced fewer attacks when they received gluten-free diets and were screened for celiac disease.</span></span></span></span><br> &nbsp; Coeliac disease, Gluten Sensitive Enteropathy, Migraine, Systematic review , Meta-analysis 621 629 http://caspjim.com/browse.php?a_code=A-10-609-4&slc_lang=en&sid=1 Gholamreza Kalvandi pezeshk1351@yahoo.com 100319475328460054577 100319475328460054577 No Associate Professor of Pediatrics Gastroenterology, Department of Pediatrics, Hamadan University of Medical Sciences, Hamadan, Iran Naser Naser Nasiri nasiri.epi@gmail.com 100319475328460054578 100319475328460054578 No School of Health, Jiroft University of Medical Sciences, Jiroft, Iran Parya Jangipour Afshar parya.afshar@gmail.com 100319475328460054579 100319475328460054579 No PhD Candidate in Epidemiology, Department of Biostatistics and Epidemiology, Faculty of Public Health, Kerman University of Medical Sciences, Kerman, Iran Hosna Ghaderi hosnaghaderi1771@gmail.com 100319475328460054580 100319475328460054580 No Department of Laboratory Sciences, Faculty of Paramedical, Kurdistan University of Medical Sciences, Kurdistan, Iran Farzad Faizi farzadfaizi90@gmail.com 100319475328460054581 100319475328460054581 No Department of Epidemiology and Biostatistics, Faculty of Medicine, Kurdistan University of Medical Sciences, Kurdistan, Iran Shoboo Rahmati shoboorahmati2014@gmail.com 100319475328460054582 100319475328460054582 Yes Department of Epidemiology and Biostatistics, Faculty of Medicine, Kurdistan University of Medical Sciences, Kurdistan, Iran