en Nephrology Nephrology Original Article Original Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt"><b><i><span style="color:blue">Background:</span></i></b><b> </b>Kidney stones are a condition that is prevalent in the geriatric group and significantly impairs their quality of life. The formation of stones may be associated with insulin resistance, which can be measured using the triglyceride-glucose (TyG) index.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Methods:</span></i></b> This cross-sectional study was part of the second phase of the Amirkola Health and Ageing Project (AHAP) Cohort, which was initiated in 2011 with a focus on individuals aged 60 years and older. The study population included a case group comprising 349 individuals diagnosed with kidney stones and a control group of 349 individuals without kidney stones, matched by age and sex. The data have been analyzed afterwards. </span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Results:</span></i></b> The mean TyG index was 4.77&plusmn;0.33 in individuals with kidney stones and 4.75&plusmn;0.34 in the group without kidney stones. The observed difference did not achieve statistical significance. Moreover, after logistic regression analyses, both crude and adjusted logistic regression analyses indicated no statistically significant relationship between the TyG index and the presence of kidney stones in the studied population.</span><br> <span style="line-height:14pt"><b><i><span style="color:blue">Conclusion:</span></i></b> The findings of this study indicate that there is no significant link between the TyG index and the occurrence of kidney stones among older adults.</span></span></span><br> &nbsp; Nephrolithiasis, Elderly, Population, Insulin Resistance, TyG Index 741 746 http://caspjim.com/browse.php?a_code=A-10-403-4&slc_lang=en&sid=1 Parsa Aghajani parsaaghajani78@gmail.com 100319475328460054656 0009-0008-7408-7328 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran Seyed Reza Hosseini hosseinirezaseyed@gmail.com 100319475328460054657 100319475328460054657 Yes Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Ali Bijani drbijani@yahoo.com 100319475328460054658 100319475328460054658 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Reza Ghadimi rezaghadimi@yahoo.com 100319475328460054659 100319475328460054659 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran