Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1394
10
1
gregorian
2016
1
1
7
1
online
1
fulltext
en
Comparison of Pyridostigmine and bisacodyl in treatment of refractory chronic constipation.
Gastroentrology
Gastroentrology
Original Article
Original Article
<p dir="ltr" style="margin: 0cm 161.6pt 0pt 0cm text-align: justify text-indent: 0cm"><span style="font-size: 12px"><span style="font-family: times new roman"><b><i><span style="color: blue">Background: </span></i></b><font color="#000000">Treatment of chronic constipation is creating one of the major problems for doctors and patients. Pyridostigmine increases the gastrointestinal motility through the effects on cholinesterase. It seems that this mechanism can reduce chronic constipation. The aim of this study was to compare the effects of pyridostigmine and bisacodyl on chronic constipation.</font></span></span></p>
<p dir="ltr" style="margin: 0cm 161.6pt 0pt 0cm text-align: justify text-indent: 0cm"><span style="font-size: 12px"><span style="font-family: times new roman"><b><i><span style="color: blue">Methods:</span></i></b><font color="#000000"> This study was conducted on 68 patients who suffered from chronic constipation. Patients were randomly divided into two groups of Pyridostigmine and bisacodyl in which each consisted of 34 patients, respectively. Bristol stool form score, straining defecation, the time of defecation, the number of defecation per week, sense of incomplete evacuation and self-digitation were collected by means of questionnaires and the data were compared.</font></span></span></p>
<p dir="ltr" style="margin: 0cm 161.6pt 0pt 0cm text-align: justify text-indent: 0cm"><span style="font-size: 12px"><span style="font-family: times new roman"><b><i><span style="color: blue">Results:</span></i></b><font color="#000000"> Sixty-eight patients with the mean age of 68.12±84.49 were studied. The mean difference in the frequency of defecation per week, VAS score, the time to defecation and the Bristol Stool form Scale in pre and post-treatment were 4.33±1.88, 5.96±2.29, 12.30±7.95 min and 2.10±0.95 in pyridostigmine group and 2.96±1.81, 4.06±2.22, 6.67±5.23 min and 1.41±0.84 in bisacodyl group, respectively. The significant difference was observed in both pyridostigmine and bisacodyl groups (P=0.005, P=0.002, P=0.002 and P=0.005, respectively). 60% and 32.3 of patients in pyridostigmine and bisacodyl groups recovered from self-digitations, respectively. In pyridostigmine and bisacodyl groups, 66.7% and 32.3 of them had improvement in the sense of incomplete defecation, respectively.</font></span></span></p>
<p dir="ltr" style="margin: 0cm 161.6pt 0pt 0cm text-align: justify text-indent: 0cm"><span style="font-size: 12px"><span style="font-family: times new roman"><b><i><span style="color: blue">Conclusion: </span></i></b><font color="#000000">Pyridostigmine and bisacodyl significantly improved the symptoms of chronic constipation similarly.</font></span></span></p>
Constipation, chronic constipation, anti-cholinesterase, pyridostigmine
19
24
http://caspjim.com/browse.php?a_code=A-10-120-5&slc_lang=en&sid=1
Iman
Soufi-Afshar
10031947532846004644
10031947532846004644
No
Department of internal Medicine, Babol University of Sciences, Babol, Iran
Aliakbar
Moghadamnia
10031947532846004645
10031947532846004645
No
Department of Pharmacology, Babol University of Sciences, Babol, Iran
Ali
Bijani
10031947532846004646
10031947532846004646
No
Social Determinant of Health Research Center
Sohrab
Kazemi
10031947532846004647
10031947532846004647
No
Cellular and Mulecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran
Javad
Shokri-Shirvani
javadshokry@gmail.com
10031947532846004648
10031947532846004648
Yes
Department of internal Medicine, Babol University of Sciences, Babol, Iran