en Gastroentrology Gastroentrology Original Article Original Article <p dir="ltr"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Background: </em></strong></span>Triple therapy with a proton pump inhibitor and two antibiotics in Helicobacter pylori (HP) eradication is widely accepted, but this combination fails in a considerable number of cases. The aim of this study was to assess the effect of clidinium-C addition on HP eradication and to investigate the efficacy and safety of clidinium-C in prevention of drugs&#39; side effects.</span></p> <p dir="ltr"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Methods:</em></strong></span> A total of 200 histopathologically confirmed HP positive peptic ulcer enrolled in this study which were randomly assigned to two treatment groups: OAC (20 mg omeprazole bid, 1000 mg amoxicillin bid and 500 mg clarithromycin bid) and OAC + clidinium-C. The effect of treatment and adverse effects were compared 6 weeks after completion of treatment. A13C-urea breath test was performed to confirm HP eradication.</span></p> <p dir="ltr"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Results:</em></strong></span> A total of 184 patients (90 in group A and 94 in group B) completed the treatment protocols. HP eradication was achieved in 71.1% in OAC versus 72.3% in OCA+clidinium-C, (P=0.73). The frequencies of abdominal pain and stool abnormality, among the side effects recorded during the therapy period, were significantly lower in group B (OCA+clidinium-C) (P=0.01 and P=0.001, respectively).</span></p> <p dir="ltr"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Conclusion:</em></strong></span> Addition of clidinium-C to OCA triple therapy decreases abdominal pain and frequency of stool abnormalities without affecting HP eradication rate. Based on these findings addition of clidinium-C may increase patient&#39;s compliance.</span></p> Clidinium-C, Helicobacter pylori eradication, Peptic ulcer, Side effects 78 81 http://caspjim.com/browse.php?a_code=A-10-38-2&slc_lang=en&sid=1 Mohammadreza Seyyedmajidi mrsmajidi55@yahoo.com 10031947532846005202 10031947532846005202 No Gastroenterologist, Golestan Research Center of Gastroenterology and Hepatology-GRCGH, Gorgan, Iran Saba Homapoor homapoorsaba@yahoo.com 10031947532846005203 10031947532846005203 No Gastroenterologist, Golestan Research Center of Gastroenterology and Hepatology-GRCGH, Gorgan, Iran Elahe Zanganeh zanganeh.e@gmail.com 10031947532846005204 10031947532846005204 No Gastroenterologist, Golestan Research Center of Gastroenterology and Hepatology-GRCGH, Gorgan, Iran Mohammad Dadjou dr.mohamad2091@yahoo.com 10031947532846005205 10031947532846005205 No Gastroenterologist, Golestan Research Center of Gastroenterology and Hepatology-GRCGH, Gorgan, Iran Shahab Eskandari-Nejad eshahab@yahoo.com 10031947532846005206 10031947532846005206 No Gastroenterologist, Golestan Research Center of Gastroenterology and Hepatology-GRCGH, Gorgan, Iran Mohammad-Hadi Tajik-Galayeri drtajikmd@yahoo.com 10031947532846005207 10031947532846005207 No Gastroenterologist, Golestan Research Center of Gastroenterology and Hepatology-GRCGH, Gorgan, Iran Jamshid Vafaeimanesh j.vafaeemanesh@muq.ac.ir 10031947532846005208 10031947532846005208 Yes Clinical Research Development Center, Qom University of Medical Sciences, Qom, Iran