en Obstetrics & Gynicology Obstetrics & Gynicology Review Article Review Article <span style="font-size:14px;"><span style="font-family:Times New Roman;"><span style="line-height:14pt">Antioxidant therapies, accessible and cost-effective, present a viable strategy for enhancing health equity in endometriosis management while potentially decreasing dependence on expensive treatments. By addressing oxidative stress, a central factor in disease advancement compounds like vitamins C, E, and D, N-acetylcysteine, curcumin, resveratrol, and melatonin offer non-hormonal avenues for symptom relief. Evidence indicates pain reduction, notably with melatonin, yet studies are small, varied, and inconclusive regarding lesion reduction. Policy recommendations emphasize funding robust multicenter trials, cautiously integrating antioxidants into clinical guidelines, educating clinicians, and empowering patients through awareness campaigns. Their low cost and safety profile make antioxidants a compelling adjunct, aligning with patient needs and promoting access in resource-limited settings. Targeted investment in biomarker research could further refine personalized treatment, improving outcomes for millions living with this chronic condition.</span></span></span> Endometriosis Pain, antioxidant, policy brief 814 818 http://caspjim.com/browse.php?a_code=A-10-869-3&slc_lang=en&sid=1 Sedighe Esmaeilzadeh sesmael2010@gmail.com 100319475328460055441 100319475328460055441 No Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Moloud Agajani Delavar moloodaghajani@yahoo.com 100319475328460055442 100319475328460055442 No Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Parvaneh Mirabi parvaneh_mirabi@yahoo.com 100319475328460055443 100319475328460055443 Yes Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.