en Surgery Surgery Original Article Original Article <p style="text-indent: 0in; margin-top: 0in; margin-right: 0in; margin-bottom: 0pt;"><font face="Times New Roman"><b><i><span style="color: blue; font-size: 10pt;">Background: </span></i></b><span style="font-size: 10pt;"><font color="#000000">Appendectomy intra-abdominal is the most frequently performed emergency surgery. This study was conducted to determine the role of postoperative antibiotics in reducing surgical site infections (SSIs) and abscess formation after open appendectomy.</font></span></font></p> <p style="text-indent: 0in; margin-top: 0in; margin-right: 0in; margin-bottom: 0pt;"><font face="Times New Roman"><b><i><span style="color: blue; font-size: 10pt;">Methods:</span></i></b><font color="#000000"><span style="font-size: 10pt;"> In the Department of Surgery, Shahid Beheshti Hospital, Babol, Iran, from October 2013<span dir="RTL"> </span>to October 2014 one hundred and fifty two patients, who underwent appendectomy for nonperforated appendicitis (NPA) and fulfilled the selection criteria, were randomized into two groups. Group A patients received a single dose of preoperative antibiotics (ceftriaxone and metronidazole) and group B patients received the same regimen, in addition, antibiotics were administered 24<span dir="RTL"> </span>hours postoperatively. Patients of </span><span style="font-size: 9pt;">both groups were followed-up for 30<span dir="RTL"> </span>days to assess the postoperative infectious </span><span style="font-size: 10pt;">complications.</span></font></font></p> <p style="text-indent: 0in; margin-top: 0in; margin-right: 0in; margin-bottom: 0pt;"><font face="Times New Roman"><b><i><span style="color: blue; font-size: 10pt;">Results:</span></i></b><span style="font-size: 10pt;"><font color="#000000"> Both groups comprised 76<span dir="RTL"> </span>patients, as well both groups were compared in baseline characteristics. Statistically, there was no significant difference in rates of SSIs between both groups. None of the patients developed intra-abdominal collection.</font></span></font></p> <p style="text-indent: 0in; margin-top: 0in; margin-right: 0in; margin-bottom: 0pt;"><font face="Times New Roman"><b><i><span style="color: blue; font-size: 10pt;">Conclusion: </span></i></b><span style="font-size: 10pt;"><font color="#000000">Single dose of preoperative antibiotics (ceftriaxone and metronidazole) was sufficient in reducing SSIs after appendectomy for NPA. Postoperative antibiotics did not add an appreciable clinical benefit in these patients.</font></span></font></p> Acute appendicitis, Postoperative antibiotics, Prophylactic, Antibiotics, Appendectomy, Surgical site infection, Nonperforated appendicitis. 104 107 http://caspjim.com/browse.php?a_code=A-10-332-1&slc_lang=en&sid=1 Seyed-Mohammadreza Sadraei-Musavi nimasadraei1358@yahoo.com 10031947532846008819 10031947532846008819 No Shahid Beheshti Hospital, Babol University of Medical Sciences, Babol, Iran Novin Nikbakhsh novinsu@hotmail.com 10031947532846008820 10031947532846008820 Yes Cancer Research Center, Health Research Institue, Babol University of Medical Sciences, Babol, Iran Aliasghar Darzi bcrdc90@yahoo.com 10031947532846008821 10031947532846008821 No Cancer Research Center, Health Research Institue, Babol University of Medical Sciences, Babol, Iran