en Pathology Pathology Original Article Original Article <span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background:</em></strong></span> Inflammatory bowel disease (IBD) is a chronic disease with a relapsing course of inflammation in the digestive system. Endoscopy and histopathology are the golden standard methods for detection and assessment of IBD. A distinct increase of fecal calprotectin level can be a useful marker for the diagnosis of IBD. The aim of this study was to evaluate the fecal calprotectin level in patients with IBD and without inflammatory diseases of the colon.<br> <span style="color:#0000FF;"><strong><em>Methods</em></strong><em>:</em></span> Calprotectin levels of patients referred to the Ayatollah Rouhani Hospital of Babol, northern Iran with clinical symptoms of colon disease were evaluated. After a week, colonoscopy and biopsy were performed on all patients and they were divided into two groups. The first group included patients with confirmed IBD and the second group included patients with diseases other than IBD, patients with IBS and healthy persons. Then the measured fecal calprotectin level was compared between the two groups before colonoscopy.<br> <span style="color:#0000FF;"><strong><em>Results:</em></strong></span> We observed correlation between calprotection in these two groups (p<0.0001). 38 (86.8%) patients in the case group and 5 (13.2%) patients in the control group had positive fecal calprotectin test and 12 (23.1%) patients in the case group and 40 (76.9%) patients in the control group had negative results. Basad on ROC curve, the cutoff point of calprotectin was 127.65 with 73% sensitivity and 89% specificity. The area under the curve was 0.83 with 95% confidence interval, 0.74-0.91 (p<0.0001).<br> <span style="color:#0000FF;"><strong><em>Conclusions: </em></strong></span>The results pointed to this fact that fecal calprotectin can be a noninvasive marker in differentiating IBD from IBS</span></span><p></p> Fecal calprotectin level, Inflammatory bowel disease, Irritable bowel syndrome 60 64 http://caspjim.com/browse.php?a_code=A-10-349-1&slc_lang=en&sid=1 Majid Sharbatdaran bcrdc90@yahoo.com 100319475328460011119 100319475328460011119 No Cancer Research Center, Health Research Institute, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran Amin Halakou dr.amin.halakou@gmail.com 100319475328460011120 100319475328460011120 No Department of pathology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran Mehrdad Kashifard bcrdc90@yahoo.com 100319475328460011121 100319475328460011121 No Cancer Research Center, Health Research Institute, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran Ali Bijani bcrdc90@yahoo.com 100319475328460011122 100319475328460011122 No Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Alireza Firozjaei bcrdc90@yahoo.com 100319475328460011123 100319475328460011123 No Cancer Research Center, Health Research Institute, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran Akram Hossaini bcrdc90@yahoo.com 100319475328460011124 100319475328460011124 No Cancer Research Center, Health Research Institute, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran Sepideh Siadati bcrdc90@yahoo.com 100319475328460011125 100319475328460011125 Yes Cancer Research Center, Health Research Institute, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran