en Biochimestry Biochimestry Original Article Original Article <p dir="ltr" style="text-align: justify"><span style="font-family: times new roman"><span style="color: rgb(0, 0, 255)"><strong><em>Background: </em></strong></span>There are studies that indicated dyshomeostasis of oxidant/antioxidant and trace elements in breast cancer patients, but the data regarding the status of these parameters in various stages of breast cancer are limited. The aim of this study was to highlight the status of these biochemical factors in various stages of breast cancer.</span></p> <p dir="ltr" style="text-align: justify"><span style="font-family: times new roman"><span style="color: rgb(0, 0, 255)"><strong><em>Methods:</em></strong></span> Fifty-eight breast cancers patients participated in this study and underwent staging work up for the assessment of disease stage.  Serum total antioxidant capacity and lipid peroxidation were determined spectrophotometically. Glutathione peroxidase (GPX), catalase (CAT) and superoxide dismutase (SOD) levels were analyzed by ELISA method. The serum level of Cu, Mn and Zn was measured by atomic absorption spectrophotometer. Student t-test and one-way analysis of variance (ANOVA) were used to compare group means.</span></p> <p dir="ltr" style="text-align: justify"><span style="font-family: times new roman"><span style="color: rgb(0, 0, 255)"><strong><em>Results:</em></strong></span> All the patients included in the study classified as mild (stages I+II) and advanced stages (stages III+IV). Patients in advanced stage had lower serum antioxidant capacity and higher lipid peroxidation levels, but the differences were not statistically differet (P=0.690 and 0.666, respectively). Patients in advanced stage had higher, but not statistically different serum levels of CAT, GPX and SOD levels (p>0.05).  Patients in both groups had to some extent similar serum Cu, Mn and Zn levels.</span></p> <p dir="ltr" style="text-align: justify"><span style="font-family: times new roman"><span style="color: rgb(0, 0, 255)"><strong><em>Conclusion: </em></strong></span>There was no evidence of remarkable discrepancy in the status of analyzed factors in various stages of breast cancer. It seems that the severity of oxidative stress in different stages of breast cancer is similar to some extent.</span></p> antioxidant/oxidant status, breast cancer, antioxidant enzymes, trace elements 31 36 http://caspjim.com/browse.php?a_code=A-10-121-2&slc_lang=en&sid=1 Azadeh Sadati Zarrini asadati@yahoo.com 10031947532846004660 10031947532846004660 No Department of Biology, Science and Research branch, Islamic Azad University, Fars, Iran Hadi Parsian hadiparsian@yahoo.com 10031947532846004661 10031947532846004661 Yes Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran Dariush Moslemi moslemi_d@yahoo.com 10031947532846004662 10031947532846004662 No Department of Radiation Oncology, Babol University of Medical Sciences, Babol, Iran Mahmood Vessal hbararpour@hotmail.com 10031947532846004663 10031947532846004663 No Department of Biology, Science and Research branch, Islamic Azad University, Fars, Iran Abbas Mosapour ab_mspr@yahoo.com 10031947532846004664 10031947532846004664 No Department of Biochemistry and Biophysics, Babol University of Medical Sciences, Babol,Iran Mahdi Gholami mgholami@yahoo.com 10031947532846004665 10031947532846004665 No Department of Biochemistry and Biophysics, Babol University of Medical Sciences, Babol,Iran Ziba Shirkhani Kelagari zshirkhani@yahoo.com 10031947532846004666 10031947532846004666 No Department of Biometric and Epidemiology, Babol University of Medical Sciences, Babol, Iran