Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1394
10
1
gregorian
2016
1
1
7
1
online
1
fulltext
en
The status of antioxidants, malondialdehyde and some trace elements in serum of patients with breast cancer
Biochimestry
Biochimestry
Original Article
Original Article
<p dir="ltr" style="text-align: justify"><span style="font-family: times new roman"><span style="color: rgb(0, 0, 255)"><strong><em>Background: </em></strong></span>There are studies that indicated dyshomeostasis of oxidant/antioxidant and trace elements in breast cancer patients, but the data regarding the status of these parameters in various stages of breast cancer are limited. The aim of this study was to highlight the status of these biochemical factors in various stages of breast cancer.</span></p>
<p dir="ltr" style="text-align: justify"><span style="font-family: times new roman"><span style="color: rgb(0, 0, 255)"><strong><em>Methods:</em></strong></span> Fifty-eight breast cancers patients participated in this study and underwent staging work up for the assessment of disease stage. Serum total antioxidant capacity and lipid peroxidation were determined spectrophotometically. Glutathione peroxidase (GPX), catalase (CAT) and superoxide dismutase (SOD) levels were analyzed by ELISA method. The serum level of Cu, Mn and Zn was measured by atomic absorption spectrophotometer. Student t-test and one-way analysis of variance (ANOVA) were used to compare group means.</span></p>
<p dir="ltr" style="text-align: justify"><span style="font-family: times new roman"><span style="color: rgb(0, 0, 255)"><strong><em>Results:</em></strong></span> All the patients included in the study classified as mild (stages I+II) and advanced stages (stages III+IV). Patients in advanced stage had lower serum antioxidant capacity and higher lipid peroxidation levels, but the differences were not statistically differet (P=0.690 and 0.666, respectively). Patients in advanced stage had higher, but not statistically different serum levels of CAT, GPX and SOD levels (p>0.05). Patients in both groups had to some extent similar serum Cu, Mn and Zn levels.</span></p>
<p dir="ltr" style="text-align: justify"><span style="font-family: times new roman"><span style="color: rgb(0, 0, 255)"><strong><em>Conclusion: </em></strong></span>There was no evidence of remarkable discrepancy in the status of analyzed factors in various stages of breast cancer. It seems that the severity of oxidative stress in different stages of breast cancer is similar to some extent.</span></p>
antioxidant/oxidant status, breast cancer, antioxidant enzymes, trace elements
31
36
http://caspjim.com/browse.php?a_code=A-10-121-2&slc_lang=en&sid=1
Azadeh
Sadati Zarrini
asadati@yahoo.com
10031947532846004660
10031947532846004660
No
Department of Biology, Science and Research branch, Islamic Azad University, Fars, Iran
Hadi
Parsian
hadiparsian@yahoo.com
10031947532846004661
10031947532846004661
Yes
Cellular and Molecular Biology Research Center, Babol University of Medical Sciences, Babol, Iran
Dariush
Moslemi
moslemi_d@yahoo.com
10031947532846004662
10031947532846004662
No
Department of Radiation Oncology, Babol University of Medical Sciences, Babol, Iran
Mahmood
Vessal
hbararpour@hotmail.com
10031947532846004663
10031947532846004663
No
Department of Biology, Science and Research branch, Islamic Azad University, Fars, Iran
Abbas
Mosapour
ab_mspr@yahoo.com
10031947532846004664
10031947532846004664
No
Department of Biochemistry and Biophysics, Babol University of Medical Sciences, Babol,Iran
Mahdi
Gholami
mgholami@yahoo.com
10031947532846004665
10031947532846004665
No
Department of Biochemistry and Biophysics, Babol University of Medical Sciences, Babol,Iran
Ziba
Shirkhani Kelagari
zshirkhani@yahoo.com
10031947532846004666
10031947532846004666
No
Department of Biometric and Epidemiology, Babol University of Medical Sciences, Babol, Iran