en Reumatology Reumatology Original Article Original Article <p style="margin: 0cm 0cm 0pt 161.6pt; text-indent: 0cm;"><font face="Times New Roman"><b><i><span style="color: blue; font-size: 10pt;">Background: </span></i></b><span style="font-size: 10pt;"><font color="#000000">Systemic lupus erythematous is an autoimmune disease associated with atherosclerotic manifestations or metabolic disturbance due to inflammation. The aim of this study was to determine frequency of metabolic syndrome (MetS) in SLE compared to healthy controls.</font></span></font></p> <p style="margin: 0cm 0cm 0pt 161.6pt; text-indent: 0cm;"><font face="Times New Roman"><b><i><span style="color: blue; font-size: 10pt;">Methods:</span></i></b><span style="font-size: 10pt;"><font color="#000000"> In this cross-sectional study, 150 SLE patients and 220 healthy volunteers were enrolled. MetS was diagnosed according to ATPIII criteria. Patients and controls were compared according to prevalence of MetS. In addition, SLE patients with and without MetS were compared according to laboratory parameters. Each patient also fulfilled a checklist about routine daily activities and diet program. Data were analyzed by SPSS-11 software.</font></span></font></p> <p style="margin: 0cm 0cm 0pt 161.6pt; text-indent: 0cm;"><font face="Times New Roman"><b><i><span style="color: blue; font-size: 10pt;">Results:</span></i></b><font color="#000000"><span style="font-size: 10pt;"> MetS was significantly lower in SLE than healthy controls (18% vs 29.1%, P=0.015). Disease manifestations, major organ involvement, serum values of complements and anti-DNA antibody and pharmacological therapy did not correlate with MetS occurrence in patients. The mean TG, FBS, systolic and diastolic BP were statistically higher in lupus patients compared to healthy volunteers in contrast to waist circumference. HDL-</span><span style="font-size: 9pt;">cholesterol serum values did not show any significant difference </span><span style="font-size: 10pt;">between two groups.</span></font></font></p> <p style="margin: 0cm 0cm 0pt 161.6pt; text-indent: 0cm;"><font face="Times New Roman"><b><i><span style="color: blue; font-size: 10pt;">Conclusion: </span></i></b><span style="font-size: 10pt;"><font color="#000000">It seems that despite higher values of blood pressure, serum lipids and glucose in lupus patients, the cumulative metabolic components were in a manner to make MetS more prevalent in healthy volunteers. As far as life habits are concerned, lupus patients in general did not exercise enough and did not go on a healthy diet despite of glucocorticoid therapy and hypertension.</font></span></font></p> systemic lupus erythematosus, SLE, lupus, metabolic syndrome, Diet, exercise, life style 195 200 http://caspjim.com/browse.php?a_code=A-10-388-1&slc_lang=en&sid=1 Mohammad Reza Hatef-Fard hatefmr@mums.ac.ir 10031947532846005987 10031947532846005987 No Rheumatic diseases research center,School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mina Khodabandeh Khodabandehm@mums.ac.ir 10031947532846005988 10031947532846005988 No School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Maryam Sahebari Sahebarim@mums.ac.ir 10031947532846005989 10031947532846005989 Yes Rheumatic Diseases Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Majid Ghayour-Mobarhan ghayourm@mums.ac.ir 10031947532846005990 10031947532846005990 No Biochemistry of Nutrition Research Center, , School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Zahra RezaieYazdi RezaieYazdiz@mums.ac.ir 10031947532846005991 10031947532846005991 No Rheumatic Diseases Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran