Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1395
7
1
gregorian
2016
10
1
7
4
online
1
fulltext
en
Both immune hormone IL-10 and parathormone tend to increase in serum of old osteoporotic people independently of 1, 25 dihydroxy vitamin D3
Imonology
Imonology
Original Article
Original Article
<p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Background: </em></strong></span>In this study, we determined the serum levels of IL-17A and IL-10 in context with 1, 2 dihydroxy vitamin D3, parathormone and Ca<sup>2+</sup>/Pi ions to investigate their pathological or protective roles respectively in bone metabolism.</span></p>
<p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Methods:</em></strong></span> The bone mineral density (BMD) was determined for 1203 participants using energy X-ray absorptiometry. Subjects with a history of diseases and using bone metabolism medications were excluded and finally serum IL-10 was measured in 82 osteoporotic and 74 healthy individuals (mean age ±SD of 71.04±6.9 and 68.58±6.9 respectively). Also, the serum level of IL-17A was assessed in 42 osteoporotic and 39 non-osteoporotic subjects (mean age±SD of 69.40±6.7 and 70.77±7.1, respectively). Serum levels of 1, 25-dihydroxyvitamin D3, Ca<sup>2+</sup>/Pi ions and parathormone were extracted from AHAP cohort data bank.</span></p>
<p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Results:</em></strong></span> IL-17A was detectable in 7.42(16.67%) osteoporotic subjects and 3.39(7.69%) normal subjects. Surprisingly, patient subjects exhibited a higher level of serum IL-10 than normal subjects (P=0.023). We found that the serum parathormone levels tend to increase in patient group (P=0.003) in comparison to normal control with no correlation with Il-10 levels. There was no significant difference between the two groups in the serum levels of 1, 25-dihydroxyvitamin D3, Ca<sup>2+</sup>and P<sub>i</sub> ions.</span></p>
<p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Conclusion: </em></strong></span>In reaction to chronic inflammation old osteoporotic patients independent of 1, 25 dihydroxy vitamin D3 may produce a higher level of IL-10 to dampen production of inflammatory cytokines including IL-17A which in turn leads to speeding up parathormone production ultimately reaching a new homeostasis status in bone metabolism with normal serum Ca<sup>2+</sup> /Pi ions.</span></p>
Osteoporosis, IL-10, IL-17A, Parathormone, 1, 25dihydroxy vitamin D3, Elderly
283
289
http://caspjim.com/browse.php?a_code=A-10-146-1&slc_lang=en&sid=1
Mohamad
Teimorian
teimorianm@gmail.com
10031947532846006810
10031947532846006810
No
Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol,Iran.
Zeinab
Jafarian
teimorianm@gmail.com
10031947532846006811
10031947532846006811
No
Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol,Iran.
Seyed-Reza
Hosseyni
hosseinirezaseyed@gmail.com
10031947532846006812
10031947532846006812
No
Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol,Iran.
Mahsa
Rahmani
teimorianm@gmail.com
10031947532846006813
10031947532846006813
No
Immunology Department, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
Mojgan
Bagherzadeh
mojan73@yahoo.com
10031947532846006814
10031947532846006814
No
Immunology Department, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
Azin
Aghmajidi
teimorianm@gmail.com
10031947532846006815
10031947532846006815
No
Immunology Department, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran
Ali
Bijani
alibijani@yahoo.com
10031947532846006816
10031947532846006816
No
Non-Communicable Pediatrics Diseases Research Center, Health Research institute, Babol University of Medical Sciences, Babol, Iran.
Hajighorban
Nooreddini
teimorianm@gmail.com
10031947532846006817
10031947532846006817
No
Departent of Radiology, Faculty of Medicine, Babol University of Medical Sciences, Babol,Iran
Amrollah
Mostafazadeh
amrolah65@yahoo.com
10031947532846006818
10031947532846006818
Yes
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.