en Biochimestry Biochimestry Original Article Original Article <p dir="ltr" style="margin: 0cm 161.6pt 0pt 0cm; text-align: justify; text-indent: 0cm;"><font face="Times New Roman"><b><i><span style="color: blue; font-size: 10pt;">Background: </span></i></b><span style="font-size: 10pt;"><font color="#000000">Alzheimer&rsquo;s disease (AD) is the most prevalent degenerative disorder of the brain among elderly individuals. Many studies indicate that oxidative stress is an important pathogenic factor which involves oxidizing macromolecules such as DNA, lipids, and proteins in AD. Green tea is a rich source of antioxidant compounds that can remove radical oxygen species. The purpose of this study was to investigate the influence of green tea consumption on markers of oxidative stress in AD.</font></span></font></p> <p dir="ltr" style="margin: 0cm 161.6pt 0pt 0cm; text-align: justify; text-indent: 0cm;"><font face="Times New Roman"><b><i><span style="color: blue; font-size: 10pt;">Methods:</span></i></b><span style="font-size: 10pt;"><font color="#000000"> In this prospective intervention study, 30 patients with severe AD were recruited. The diagnosis of AD was made based on the National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer&rsquo;s disease and Related Disorders Association (NINCDS/ADRDA) criteria. Brain magnetic resonance imaging (MRI) and computed tomography (CT) scan as well as Mini-Mental State Examination (MMSE) were performed for all participants in which four green tea pills were administered daily for 2 months (2 g/day in 2 divided doses). The plasma total antioxidant capacity, 8-hydroxy-2&rsquo;-deoxyguanosine levels (8-OHdG), malondialdehyde (MDA)</font><span style="color: red;">,</span><font color="#000000"> carbonyl content, and MMSE scores were measured at baseline and at the end of the study period.</font></span></font></p> <p dir="ltr" style="margin: 0cm 161.6pt 0pt 0cm; text-align: justify; text-indent: 0cm;"><font face="Times New Roman"><b><i><span style="color: blue; font-size: 10pt;">Results:</span></i></b><span style="font-size: 10pt;"><font color="#000000"> The levels of MDA, 8-OHdG and carbonyl decreased significantly as compared to baseline values (P=0.002, P=0.001 and P=0.037, respectively). Whereas, the total antioxidant capacity of plasma and MMSE scores significantly increased at end point (P=0.000, P=0.043, respectively).</font></span></font></p> <p dir="ltr" style="margin: 0cm 161.6pt 0pt 0cm; text-align: justify; text-indent: 0cm;"><font face="Times New Roman"><b><i><span style="color: blue; font-size: 10pt;">Conclusion: </span></i></b><span style="font-size: 10pt;"><font color="#000000">The findings indicate that consumption of green tea for two months by with the improvement of antioxidant system exerts beneficial effect on cognitive function.</font></span></font></p> Alzheimer’s disease, Antioxidants, Green tea, Oxidative stress, Cognitive function. 188 194 http://caspjim.com/browse.php?a_code=A-10-71-1&slc_lang=en&sid=1 Hourolein Arab hourolein.arab@yahoo.com 100319475328460012803 100319475328460012803 No Student research center, Babol University of Medical Sciences, Babol, Iran. Soleiman Mahjoub smahjoub20@gmail.com 100319475328460012804 100319475328460012804 Yes Cellular and Molecular Biology Research Center, Health Research Institute Karimollah Hajian-Tilaki drhajian@yahoo.com 100319475328460012805 100319475328460012805 No Babol University of Medical Sciences Mehdi Moghadasi smahjoub20@yahoo.com 100319475328460012806 100319475328460012806 No Mehr-Avaran-Shomal nursing home