Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1395
1
1
gregorian
2016
4
1
7
2
online
1
fulltext
en
Efficiency and outcome of non-invasive versus invasive positive pressure ventilation therapy in respiratory failure due to chronic obstructive pulmonary disease
Pulmonology
Pulmonology
Original Article
Original Article
<p dir="ltr" style="text-align: justify;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Background:</em></strong></span> Application noninvasive ventilation in the patients with exacerbation of chronic obstructive pulmonary disease (COPD) reduced mortality. This case-control study was designed to compare efficiency and outcome of non-invasive (NIV) versus invasive positive pressure ventilation (IPPV) in respiratory failure due to COPD</span></p>
<p dir="ltr" style="text-align: justify;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Methods:</em></strong></span> The patients were assigned to NIV or IPPV intermittantly.The clinical parameters, including RR (respiratory rate), BP (blood pressure), HR (heart rate) and PH, PaCO2, PaO2 before and 1, 4 and 24 h after treatment were measured. Demographic information such as age, sex, severity of disease based on APACHE score, length of stay and outcome were recorded</span></p>
<p dir="ltr" style="text-align: justify;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Results:</em></strong></span> Fifty patients were enrolled in the NIV group and 50 patients in IPPV. The mean age was 70.5 in NIV and 63.9 in invasive ventilation group (p>0.05). In IPPV group, the average values of PH: PCO2: and PO2, were 7.22±0.11, 69.64 <u>+</u> 24.25: and 68.86±24.41 .In NIV, the respective values were 7.30±0.07, 83.94±18.95, and 60.60±19.88. In NIV group, after 1, 4 and 24 h treatment, the clinical and ventilation parameters were stable. The mean APACHE score in was IPPV, 26.46±5.45 and in NIV was 12.26±5.54 (p<0.05). The average length of hospital stay in IPPV was 15.90±10 and in NIV 8.12±6.49 days (p<0.05). The total mortality in the NIV was 4 (8%) and in IPPV, 27 patients (54%) (p<0.05).</span></p>
<p dir="ltr" style="text-align: justify;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Conclusion:</em></strong></span> This study indicates that using NIPPV is a useful therapeutic mode of treatment for respiratory failure with acceptable success rate and lower mortality. The application of NIPPV reduces hospital stay, intubation and its consequent complications</span></p>
Non-invasive ventilation, Invasive mechanical ventilation, acute respiratory failure, Mortality, Chronic obstructive pulmonary disease
99
104
http://caspjim.com/browse.php?a_code=A-10-153-1&slc_lang=en&sid=1
Valiollah
Amri-Maleh
valiamri@yahoo.com
10031947532846005221
10031947532846005221
No
Babol University of Medical Science
Mahmood
Monadi
dr.monadi@yahoo.com
10031947532846005222
10031947532846005222
Yes
Babol University of Medical Science
Behzad
Hidari
Bheidari6@gmail.com
10031947532846005223
10031947532846005223
No
Babol University of Medical Science
Parviz
Amri-Maleh
pamrimaleh@yahoo.com
10031947532846005224
10031947532846005224
No
Babol University of Medical Science
Ali
Bijani
mojy_rad@yahoo.com
10031947532846005225
10031947532846005225
No
Babol University of Medical Science