en Internal Internal Original Article Original Article <p dir="ltr" style="text-align: justify;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Background: </em></strong></span>Benign paroxysmal positional vertigo (BPPV) is linked to vitamin D deficiency. This clinical trial aimed to determine the influence of vitamin D supplementation on intensity of BPPV.</span></p> <p dir="ltr" style="text-align: justify;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Methods:</em></strong></span> The study population was selected consecutively and the diagnosis of BPPV was made by history and clinical examination and exclusion of other conditions. Intensity of BPVV was assessed based on VAS score <strong>(</strong>0-10<strong>)</strong>. Serum 25-hydroxyvitamin D (25-OHD) was measured using ELISA method and levels < 20 ng/ml was considered a deficiency. All patients received rehabilitation treatment using Epley&#39;s maneuver one time per week for one month. Serum 25-OHD deficient patients were classified as treated and non-treated groups (rehabilitation with or without 50.000 IU cholecalciferol weekly for two months).The results of treatment were compared with vitamin D sufficient group as control. All patients were followed-up for 6 months.</span></p> <p dir="ltr" style="text-align: justify;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Results:</em></strong></span> After two months of treatment, in both vitamin D treated and non-treated groups the intensity of BPPV decreased significantly as compared with control (P=0.001 for both groups) but at endpoint, the intensity of BPPV aggravated and regressed to the baseline value in vitamin D deficient non-treated group (P=0.001) whereas, in vitamin D treated group, improvement of BPPV remained stable and unchanged over the study period.</span></p> <p dir="ltr" style="text-align: justify;"><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Conclusion:</em></strong></span> This study indicates that correction of vitamin D deficiency in BPPV provides additional benefit to rehabilitation therapy (Epley maneuver) regarding duration of improvement. These findings suggest serum 25-OHD measurement in recurrent BPPV.</span></p> Benign paroxysmal positional vertigo, Intensity, Vitamin D, Rehabilitation Therapy 93 98 http://caspjim.com/browse.php?a_code=A-10-263-4&slc_lang=en&sid=1 Mahboobeh Sheikhzadeh m.sheikhzadeh2@yahoo.com 10031947532846005215 10031947532846005215 No University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Yones Lotfi yones1333@gmail.com 10031947532846005216 10031947532846005216 Yes University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Abdollah Mousavi amoossavi@gmail.com 10031947532846005217 10031947532846005217 No University of Social Welfare and Rehabilitation Sciences, Tehran, Iran Behzad Heidari B.heidari@yahoo.com 10031947532846005218 10031947532846005218 No Ganjafrooz Street, Babol University of Medical Science, Iran Mohsen Monadi monadi.mohsen@yahoo.com 10031947532846005219 10031947532846005219 No Clinical Research Development Unit of Rouhani Hospital, Master of Science of Department of Audiology, Babol University of Medical Sciences, Babol, Iran. Enayatollah Bakhshi bakhshi@razi.tums.ac.ir 10031947532846005220 10031947532846005220 No University of Social Welfare and Rehabilitation Sciences, Tehran, Iran