Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1395
10
1
gregorian
2017
1
1
8
1
online
1
fulltext
en
Prevalence of diabetes, impaired fasting glucose and impaired glucose tolerance in patients with thalassemia major in Iran: A meta-analysis
Endocrinology
Endocrinology
Review Article
Review Article
<p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Background: </em></strong></span>This study aimed to investigate the prevalence of diabetes, impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) in Iranian patients with thalassemia major.</span></p>
<p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Methods:</em></strong></span> The current study has been conducted based on PRISMA guideline. To obtain the documents, Persian and English scientific databases such as Magiran, Iranmedex, SID, Medlib, IranDoc, Scopus, PubMed, ScienceDirect, Cochrane, Web of Science, Springer, Wiley Online Library as well as Google Scholar were searched until December 2015. All steps of the study were conducted by two authors independently. To the high heterogeneity of the studies, the random effect model was used to combine studies. Data were analyzed using STATA Version 11.1 software.</span></p>
<p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Results:</em></strong></span> Thirty-two studies involving 3959 major thalassemia patients with mean age of 16.83 years were included in the meta-analysis. The prevalence of diabetes in Iranian patients with thalassemia major was estimated as 9% (95% CI: 6.8-10.5) and estimated rate was 12.6% (95% CI: 6.1-19.1) for males and 10.8% (95% CI: 8.2-14.5) for females. The prevalence of IFG and IGT were 12.9% (95% CI: 7-18.8) and 9.6% (95% CI: 6.6-12.5) respectively. No relationship between serum ferritin and development of diabetes was noted.</span></p>
<p><span style="font-family: times new roman;"><span style="color: rgb(0, 0, 255);"><strong><em>Conclusion: </em></strong></span>The prevalence of diabetes, IFG, and IGT in patients with thalassemia major in Iran is high and accordingly requires new management strategies and policies to minimize endocrine disorders in Iranian patients with thalassemia major. Screening of patients for the early diagnosis of endocrine disorders particularly diabetes, IFG, and IGT is recommended.</span></p>
Diabetes, Impaired Fasting Glucose, Impaired Glucose Tolerance, Ferritin Thalassemia Major, Iran, Meta-analysis
1
15
http://caspjim.com/browse.php?a_code=A-10-509-1&slc_lang=en&sid=1
Milad
Azami
milad98azami@gmail.com
100319475328460016517
100319475328460016517
No
Student Research Committee
Ali
Sharifi
100319475328460016518
100319475328460016518
No
3- Department of Interstice Medicine, Faculty of Medicine, Ilam University of Medical Sciences, Ilam, Iran
Siros
Norozi
100319475328460016519
100319475328460016519
No
Akram
Mansouri
100319475328460016520
100319475328460016520
No
Kourosh
Sayemiri
100319475328460016516
100319475328460016516
Yes
Department of Biostatistics, Research Center for Prevention of Psychosocial Impairment, Ilam University of Medical Sciences , Ilam, Iran