en pharmacology pharmacology Original Article Original Article <p dir="ltr" style="text-align: justify;"><span style="font-size: 12px;"><span style="font-family: times new roman,times,serif;"><span style="color: rgb(0, 0, 255);"><strong><em>Background: </em></strong></span>Gastric cancer (GC) is one of the most common Cancers in the world and Helicobacter pylori (HP) infection is considered a causative factor. The aim of this study was to determine the characteristics and the associated factors of (GC) in a small cohort.</span></span></p> <p dir="ltr" style="text-align: justify;"><span style="font-size: 12px;"><span style="font-family: times new roman,times,serif;"><span style="color: rgb(0, 0, 255);"><strong><em>Methods:</em></strong></span> Overall, 54 patients with diagnosed gastric cancer were followed-up at the Department of Gastroenterology & Hepatology at Baqiyatallah University of Medical Sciences. 37 (68.5%) of them were positive for <em>H pylori</em> infection in histopathological evaluations. Univariate and multivariate regression analyses were used to determine the associations of demographic features and HP infection status with GC characteristics and prognosis.</span></span></p> <p dir="ltr" style="text-align: justify;"><span style="font-size: 12px;"><span style="font-family: times new roman,times,serif;"><span style="color: rgb(0, 0, 255);"><strong><em>Results:</em></strong></span> Univariate analysis showed female gender (odds ratio (OR): 6.53; 95% confidence interval (95%CI): 1.59-26.8; P=0.008), and illiteracy (compared to intermediate education; OR: 5.9, 95%CI: 1.37-25.43; p=0.05) were associated significantly with higher rate of HP infection. After a mean&plusmn;SD follow-up duration of 254&plusmn;329 months, only female gender was significantly associated with HP infection in GC (OR:4.56; 95% CI: 1.0-21.76; P=0.05). <em>H pylori</em> positive patients had significantly higher grade of GC (OR: 3.97; 95% CI: 1.0-16.16; P=0.05), and a trend toward greater GC stage (OR: 4.46, 95% CI: 9.39-21.23; p=0.06). There was no association between survival rate and <em>H pylori</em> infection.</span></span></p> <p dir="ltr" style="text-align: justify;"><span style="font-size: 12px;"><span style="font-family: times new roman,times,serif;"><span style="color: rgb(0, 0, 255);"><strong><em>Conclusion:</em></strong></span> In the current study, we found a significant association of female gender with GN and an association of higher grade of GC with female gender. These findings may indicate a sex disparity in susceptibility to HP infection regarding GC future studies of larger populations are recommended.</span></span></p> Helicobacter pylori, Gender, Female, Stomach cancer, Gastric carcinoma, Iran 136 141 http://caspjim.com/browse.php?a_code=A-10-256-2&slc_lang=en&sid=1 Shahram Agah 10031947532846005295 10031947532846005295 No Colorectal Research Center; Iran University of Medical Sciences, Tehran Hossein Khedmat 10031947532846005296 10031947532846005296 No Baqiyatallah Research Center for Gastroenterology and Liver Disease; Baqiyatallah University of Medical Sciences, Tehran, Iran Mohammad Ebrahim Ghamar-Chehred 10031947532846005297 10031947532846005297 No Baqiyatallah Research Center for Gastroenterology and Liver Disease; Baqiyatallah University of Medical Sciences, Tehran, Iran Reza Hadi 10031947532846005298 10031947532846005298 No Baqiyatallah Research Center for Gastroenterology and Liver Disease; Baqiyatallah University of Medical Sciences, Tehran, Iran Aghdas Aghaei khedmat.h@gmail.com 10031947532846005299 10031947532846005299 Yes Baqiyatallah Research Center for Gastroenterology and Liver Disease; Baqiyatallah University of Medical Sciences, Tehran, Iran