en Reumatology Reumatology Review Article Review Article <p style="margin: 0cm 0cm 0pt 161.6pt; text-indent: 0cm;"><font face="Times New Roman"><b><i><span style="color: blue; font-size: 10pt;">Background: </span></i></b><span style="font-size: 10pt;"><font color="#000000">Several factors are associated with the development or exacerbation of pain in knee osteoarthritis (KOA). In this study, we reviewed this context based on relevant studies.</font></span></font></p> <div style="margin: 0cm 0cm 0pt 161.6pt; text-indent: 0cm;"><font face="Times New Roman"><b><i><span style="color: blue; font-size: 10pt;">Methods:</span></i></b><span style="font-size: 10pt;"><font color="#000000"> Recent published studies which have addressed the relationship between pain and KOA were summarized.</font></span></font></div> <p style="margin: 0cm 0cm 0pt 161.6pt; text-indent: 0cm;"><font face="Times New Roman"><b><i><span style="color: blue; font-size: 10pt;">Results:</span></i></b><span style="font-size: 10pt;"><font color="#000000"> Correlates of the clinical, demographic features, laboratory tests and abnormalities on radiographic as well as magnetic resonance imaging (MRI) with the knee pain have been discussed. The results indicated that many factors such as synovitis, synovial effusion, obesity, as well as structural lesions determined by MRI or radiographic examination, serum cytokines, inflammatory markers are determinants of pain in KOA. </font></span></font></p> <p style="margin: 0cm 0cm 0pt 161.6pt; text-indent: 0cm;"><font face="Times New Roman"><b><i><span style="color: blue; font-size: 10pt;">Conclusion:</span></i></b><span style="color: rgb(153, 51, 0); font-size: 10pt;"> </span><span style="font-size: 10pt;"><font color="#000000">This context requires further investigations for identification of additional factors which initiate pain in asymptomatic KOA</font></span></font></p> Knee osteoarthritis, Pain, Determinants, Synovitis, C-reactive protein, Structural lesions 153 161 http://caspjim.com/browse.php?a_code=A-10-263-6&slc_lang=en&sid=1 Behzad Heidari heidaribeh@yahoo.com 10031947532846005946 10031947532846005946 No Mobility Impairment Research Center, the Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran Karimollah Hajian-Tilaki mojy_rad@yahoo.com 10031947532846005947 10031947532846005947 No Department of Social Medicine, Department of Statistics, Babol University of Medical Sciences, Babol, Iran Mansour Babaei babaeim47@yahoo.com 10031947532846005948 10031947532846005948 Yes Department of Internal medicine, Ayatollah Rouhani Hospital Division of Rheumatology, Babol University of Medical Sciences, Babol, Iran