en Endocrinology Endocrinology Short Communication Short Communication <p><span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background: </em></strong></span>Limited information exists between the associations of diabetes mellitus (DM) and solar lentigo (SL); a benign, common skin lesion characterized by hyperpigmented macules.<br> <span style="color:#0000FF;"><strong><em>Methods: </em></strong></span>This study was conducted on 90 patients diagnosed with DM and their age and sex matched controls who were referred to the Departments of Endocrinology at Babol University of Medical Science in Northern of Iran from January 2013 to December 2015. All demographic data including age, gender, occupation, family history of DM, estimated average sun exposure and presence of skin lesions were collected and analyzed.<br> <span style="color:#0000FF;"><strong><em>Results: </em></strong></span>Presence of SL was significantly higher among patients with DM compared to controls (61.9% vs 33.6%, P<0.001). After adjusting for age, sex and sun exposure rate, results indicated that DM was independently associated with the presence of SL (p=0.002). Stratifying patients based on gender, indicated that DM was significantly associated with SL in females (p=0.03), but not in male patients (p=0.06).<br> <span style="color:#0000FF;"><strong><em>Conclusion: </em></strong></span>The findings of the present study indicate that DM is an independent risk factor for the occurrence of SL lesions. These findings could represent a novel association between DM as a chronic oxidation state and SL as an early sign of aging.</span></span></p> <p></p> <p></p> Diabetes mellitus- lentigo- Skin manifestations- skin lesions 317 320 http://caspjim.com/browse.php?a_code=A-10-418-2&slc_lang=en&sid=1 Bobak Moazzami moazzami.bobak@gmail.com 100319475328460010072 100319475328460010072 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran. Niloofar Razavi niloofarrazavi530@gmail.com 100319475328460010073 100319475328460010073 No Student Research Committee, Babol University of Medical Sciences, Babol, Iran. Mansour Babaei m.babaei@mubabol.ac.ir 100319475328460010074 100319475328460010074 No Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. Motahareh Haghparast moazzami.bobak@gmail.com 100319475328460010075 100319475328460010075 No Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran. Mohammad Ali Bayani bayani.ma49@yahoo.com 100319475328460010076 100319475328460010076 Yes Social Determinants of Health (SDH) Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran