en Neurology Neurology Original Article Original Article <p><span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background: </em></strong></span>Autonomic neuropathy and vital organ dysfunctions are the known complications in type 2 diabetes Mellitus (DM). Genetic endowments involving individuals make subtle differences in physiological systems, particularly at the time of sickness. Hence, the presented study was designed to evaluate the vasomotor system in healthy people and type 2 DM cases for determining any functionality differences between the mentioned groups.</span></span></p> <p><span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Methods:</em></strong></span> Sixty patients with type 2 diabetes (case group) and sixty healthy subjects (control group) matched for age and sex were enrolled in the study. Then, the performance of vasomotor system was assessed using valsalva maneuver, cold pressor, sustained hand-grip and mental arithmetic tests and the differences were determined via statistical methods.</span></span></p> <p><span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Results:</em></strong> </span>According to our findings, abnormal response to valsalva maneuver was found in the case group (P=0.028) and the same response was seen about mental arithmetic evaluations. In the case of cold pressor and sustained hand-grip tests, remarkable differences were not found in both groups. Important differences were also found among vasomotor dysfunction and the time of DM labeling.</span></span></p> <p><span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Conclusion: </em></strong></span>This study showed a higher incidence of vasomotor dysfunction in DM patients. However, revision in cold pressor and sustained hand-grip tests definition as well as methodology was recommended.</span></span></p> Diabetes, Vasomotor, Valsalva, Sustained hand-grip, Cold pressor, Mental arithmetic 183 189 http://caspjim.com/browse.php?a_code=A-10-594-1&slc_lang=en&sid=1 Mehdi Maghbooli m.maghbooli@zums.ac.ir 10031947532846009151 10031947532846009151 No Department of Neurology, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran Hossein Chiti dr.chiti@zums.ac.ir 10031947532846009152 10031947532846009152 No Zanjan Metabolic Disease Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. Sakineh Taheri dr.chiti@zums.ac.ir 10031947532846009153 10031947532846009153 No Zanjan Metabolic Disease Research Center, Zanjan University of Medical Sciences, Zanjan, Iran. Masoud Asadi-Khiavi makhiavi@gmail.com 10031947532846009154 10031947532846009154 Yes Zanjan Applied Pharmacology Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.