en Oncology Oncology Review Article Review Article <p class="yiv1298762354msonormal" style="margin-top:0cm;text-align:justify; line-height:150%;tab-stops:center 234.0pt"><span style="font-family:times new roman;">Immunotherapy has been used for years in many types of cancer therapy. Recently, cancer immunotherapy has focused on mechanisms which can enhance the development of cell-mediated immunity. Anticancer medications are administered to inhibit immunosuppressive factors such as nagalase enzyme, which is produced by neoplastic cells and destroys macrophage activating factor (Gc-MAF). Anti-neoplastics medications can also enhance immune-cell activity against tumors. Such medications show great potential in cancer immunotherapy using natural human mechanisms against neoplasms.</span></p> Cancer, Immunotherapy, Macrophage activating factor, GC-MAF, Vitamin D. 228 238 http://caspjim.com/browse.php?a_code=A-10-605-1&slc_lang=en&sid=1 Ehsan Saburi ehsansaburi@yahoo.com 100319475328460010644 100319475328460010644 No Molecular Medicine Department, Zanjan University of medical Sciences, Zanjan, Iran. Amin Saburi aminsaburi@yahoo.com 100319475328460010645 100319475328460010645 No Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran Mostafa Ghanei mghaneister@gmail.com 100319475328460010646 100319475328460010646 Yes Chemical Injuries Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran