en Ophtalmology Ophtalmology Original Article Original Article <span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background:</em></strong></span> Thyroid-associated eye disease (TED), previously known as Graves&rsquo; ophthalmopathy is a cosmetically and functionally debilitating disease that is seen worldwide. The aim of this study was to evaluate the prevalence and clinical severity of ocular manifestations of Graves&rsquo; disease according to sex, age and duration in northern Iran.<br> <span style="color:#0000FF;"><strong><em>Methods</em></strong><em>:</em></span> Between April 2011 and March 2012, 105 patients with Graves&rsquo; disease, underwent ophthalmic examination, including ocular motility, exophthalmometry, intraocular pressure (IOP), slit lamp and fundoscopy. Patients received scores according to modified Werner&rsquo;s NO SPECS classification.<br> <span style="color:#0000FF;"><strong><em>Results:</em></strong> </span>Ocular involvement was found in 70 patients with established Graves&rsquo;s disease. The mean age was 35.0 years, (SD 13.0, range 15 to 69). The most common ocular findings were exophthalmometric proptosis of more than 20 mm (63.8%), lid lag (55.7%), lid retraction (52.8%) and tearing (38.6%). Almost 70% of patients had bilateral involvement. Elevated IOP was seen in 15 (25.4%) patients, and was significantly related to proptosis (P=0.007). More than half of the patients (n=36, 52.2%) had a modified Werner&rsquo;s NO SPECS score of 3.00. Clinical severity as shown by the increasing number of signs and symptoms per patient was correlated to increasing age (r=0.31, P=0.01) but not to gender (P=0.17).<br> <span style="color:#0000FF;"><strong><em>Conclusions:</em></strong></span> Both functional (ocular motility disorders, increased IOP) and cosmetic (proptosis, periorbital edema) sequels are common ocular presentations in patients with Graves&#39; disease. Proptosis was the most common finding in this study and was associated with elevated IOP. Clinical severity was found to correlate to increasing age.</span></span><br> <p></p> Graves’ disease, thyroid-associated eye disease, proptosis, no specs 178 183 http://caspjim.com/browse.php?a_code=A-10-263-9&slc_lang=en&sid=1 Sara Gharib saragharib@yahoo.com 100319475328460012028 100319475328460012028 Yes Department Ophthalmology, Clinical Research Development Unit of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran Zoleika Moazezi zmoazezi@yahoo.com 100319475328460012029 100319475328460012029 No Department of Internal Medicine, Ayatollah Rouhani Hospital, Clinical Research Development Unit of Rouhani Hospital Babol University of Medical Sciences, Babol, Iran. Mohammadali Bayani rohanresearch88@gmail.com 100319475328460012030 100319475328460012030 No Department of Internal Medicine, Ayatollah Rouhani Hospital, Clinical Research Development Unit of Rouhani Hospital Babol University of Medical Sciences, Babol, Iran.