Caspian Journal of Internal Medicine

en Inflammatory myopathies in a patient with Darier's disease, a possible association Dermathology Dermathology case report case report Background: Darier disease (DD) is an autosomal dominant genetic disorder which develops from a mutation in the ATP2A2 gene. Inflammatory myopathies (IM) are the largest group of potentially treatable myopathies. In this case, we report development of IM in a patient with DD for the second time in the literature. Case presentation: The patient is a 59-year-old female, a known case of  DD, who developed proximal muscle weakness 2 weeks prior to admission. Elevated muscle-enzymes, as well as typical electromyographic and radiologic confirmed the diagnosis of IM. Conclusions: Abnormalities in intracellular calcium homeostasis may explain the association between DM and DD, therefore it is noteworthy to keep this association in mind and conduct more research regarding this issue Darier Disease, Inflammatory myopathy, dermatomyositis, poly myositis 201 203 http://caspjim.com/browse.php?a_code=A-10-650-1&slc_lang=en&sid=1 Kaveh Gharaeinejad gharaeek36@gmail.com 100319475328460012085 100319475328460012085 No Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran Hojat Eftekhari dr.he.der@gmail.com 100319475328460012086 100319475328460012086 Yes Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran rana rafiei rafieirana@yahoo.com 100319475328460012087 100319475328460012087 No Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran Abbas Darjani gharaei-kaveh@gums.ac.ir 100319475328460012088 100319475328460012088 No Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran Narges Alizadeh narges.alizadeh7@gmail.com 100319475328460012089 100319475328460012089 No Department of Dermatology, Razi Hospital, Guilan University of Medical Sciences, Rasht, Iran