Caspian Journal of Internal Medicine

en Q-T interval prolongation in cirrhosis: Relationship and severity Internal Internal Original Article Original Article Background: Cirrhosis as the final stage of progressive fibrosis of liver can affect other organs such as lungs, kidneys and heart. "Cirrhotic cardiomyopathy" involves the electrophysiological abnormalities such as QT interval prolongation. We assessed correlation between corrected QT interval prolongation and severity of cirrhosis based on Child Classification in each ECG lead. Methods: In this case-control study, the patients attending the outpatient clinic and inpatient department of internal medicine of Velayat Hospital in Qazvin were enrolled from September 2014 to July 2015. Total samples were 74 patients, half of which were used as controls. Cirrhosis severity was determined as per Child Classification. Both groups had Ca2+, Mg2+, K+ tested and 12- lead ECG was obtained. The QT interval was corrected by two different formulas: (1) QTc=QT/√RR (QTc1); (2) QTc=QT+1.75 (heart rate-60) (QTc2). To analyze the data, the software SPSS Version 16 and Mann-Whitney, Pearson’s chisquare test-Kruskal-Wallis, and t-tests were used. Results: The mean of QTc1 and QTc2 was longer in cirrhotics than the control group. There was a significant correlation between Child score and length of QTc1 in leads: III (p=0.032), AVL (p=0.041), V2 (p=0.049), V6 (p=0.015). There were significant differences in length of QTc1 in leads: V3 (p=0.031) and V6 (p=0.021); and QTc2 in lead V3 (p=0.039) between Child Classification. Conclusions: Cirrhosis can induce QTc interval prolongation. Lead V3 has statistically significant correlation with the severity of cirrhosis based on child classification. We propose that QT interval prolongation be added as a criterion for prioritizing liver transplantation. Cardiomyopathy, Prolonged QT interval, Severity of cirrhosis, Child score 239 243 http://caspjim.com/browse.php?a_code=A-10-669-1&slc_lang=en&sid=1 Ali Akbar Hajiaghamohammadi ahmohammadi@qums.ac.ir 100319475328460013038 100319475328460013038 No Department of Internal Medecine, Metabolic Disease Research Center, Qazvin University of Medical Sciences, Qazvin, Iran Mohammad Mahdi Daee mmdamir@yahoo.com 100319475328460013039 100319475328460013039 No Department of Cardiology, Boali Hospital, Qazvin University of Medical Sciences, Qazvin, Iran Ali Zargar alizargar78@yahoo.com 100319475328460013040 100319475328460013040 No Department of Internal Medecine, Metabolic Disease Research Center, Qazvin University of Medical Sciences, Qazvin, Iran Somayeh Ahmadi Gooraji ahmadisomayeh90@gmail.com 100319475328460013041 100319475328460013041 No Velayat Clinical Research Development Unit, Qazvin University of Medical Sciences, Qazvin, Iran Alfred Rahban arahban@roadrunner.com 100319475328460013042 100319475328460013042 No Hollywood Presbyterian Medical Center, Midway Hospital Medical Center, Los Angles, California, USA Fereshte Attaran Fereshte_attaran@yahoo.com 100319475328460013043 100319475328460013043 Yes Department of Internal Medecine, Metabolic Disease Research Center, Qazvin University of Medical Sciences, Qazvin, Iran