Caspian Journal of Internal Medicine
1
Caspian J Intern Med
Medical Sciences
http://caspjim.com
1
admin
2008-6164
2008-6172
8
10.22088/cjim
14
8888
13
en
jalali
1396
10
1
gregorian
2018
1
1
9
1
online
1
fulltext
en
The efficacy and safety of two different doses of caffeine in respiratory function of preterm infants
Pediatrics
Pediatrics
Original Article
Original Article
<span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background:</em></strong> </span>Caffeine is widely used for prevention of apnea and helps successful extubation from mechanical ventilation. It facilitates the transition from invasive to noninvasive support and reduces duration of continuous positive airway pressure (CPAP) in preterm infants. The optimum caffeine dose in preterm infants has not been well-studied in terms of benefits and risks. We compared efficacy and safety of once versus twice-daily caffeine dose in premature infants.<br>
<span style="color:#0000FF;"><strong><em>Methods</em></strong><em>:</em></span> This study was a randomized clinical trial conducted in Bu-Ali Sina Teaching Hospital, Sari. Patients with gestational age of <37 weeks were included. Both groups received 20 mg/kg loading dose of caffeine intravenously followed by maintenance dose of 5 mg/kg/day in group 1 or 2.5 mg/kg every 12 hours in group 2. Extubation failure, CPAP failure and possibly adverse reactions were evaluated.<br>
<span style="color:#0000FF;"><strong><em>Results:</em></strong> </span>The mean of gestational age and birth weight were 32.27±3.23 (weeks) and 1824.5±702.54 (gr), respectively. The rate of extubation and CPAP failure and length of NICU stay were lower in twice-daily-group with no statistically significant difference. The means of O<sup>2</sup> saturations on the first three days of caffeine therapy were higher in twice-daily-group. Caffeine was generally safe and well tolerated.<br>
<span style="color:#0000FF;"><strong><em>Conclusions:</em></strong></span> This study, which assayed short-term effects of caffeine, showed that twice daily caffeine maintenance dose was related to more benefits in facilitating extubation or prevention of CPAP failure in preterm infants. However, there was not statistically significant difference between two groups.</span></span><br>
<p></p>
Caffeine, Extubation failure, CPAP failure, Preterm infants
46
53
http://caspjim.com/browse.php?a_code=A-10-686-1&slc_lang=en&sid=1
Fatemeh
Faramarzi
faramarzif1984@gmail.com
100319475328460011107
100319475328460011107
No
Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Mohamadreza
Shiran
Mr.Shiran@gmail.com
100319475328460011108
100319475328460011108
No
Immunogenetics Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Mohamadreza
Rafati
mrrafati@mazums.ac.ir
100319475328460011109
100319475328460011109
Yes
Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Roya
Farhadi
dr.royafarhadi@gmail.com
100319475328460011110
100319475328460011110
No
Department of Pediatrics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
Ebrahim
Salehifar
100319475328460011111
100319475328460011111
No
Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
Maryam
Nakhshab
100319475328460011112
100319475328460011112
No
Department of Pediatrics, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.