en Health Health Original Article Original Article <p><span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background: </em></strong></span>The low density lipoprotein cholestrol (LDL-C) has an important role in the pathogenesis of cardiovascular disease but its association and predictive accuracy with metabolic syndrome (MetS) remains controversial. The objective of this study was to investigate the association and predictive ability of LDL-C with MetS.<br> <span style="color:#0000FF;"><strong><em>Methods: </em></strong></span>We analyzed the data from a population-based cross-sectional study conducted on representative samples of an Iranian adult population. The demographic data, anthropometric measures and the lipid profiles were measured with standard methods, and MetS was diagnosed by ATP III criteria. Logistic regression model and ROC analysis were used to estimate the predictive accuracy of LDL-C and its association with MetS.<br> <span style="color:#0000FF;"><strong><em>Results: </em></strong></span>The mean age (&plusmn;SD) of participants with and without MetS was 47.6&plusmn;12.5 years and 39.1&plusmn;12.9 years, respectively (p=0.001). All anthropometric measures (body mass index, waist circumference, waist to hip ratio, waist to height ratio), systolic blood pressure, total cholesterol, triglycerides and fasting blood glucose were significantly higher in MetS, but a significantly higher difference in LDL-C was observed only in women. Accuracy of LDL-C in predicting MetS for men and women was 0.48 (95% CI: 0.43-0.54) and 0.55 (95% CI: 0.51-0.60), respectively. The unadjusted and adjusted odds ratios of different quartiles of LDL-C compared with 1^st quartile did not reach to a significant level.<br> <span style="color:#0000FF;"><strong><em>Conclusion: </em></strong></span>Serum LDL-C level is not significantly associated with MetS but exhibits a weak ability in predicting MetS in women.</span></span></p> Low density lipoprotein cholesterol, metabolic syndrome, Iranian adults 289 295 http://caspjim.com/browse.php?a_code=A-10-133-3&slc_lang=en&sid=1 Karimollah Hajian-Tilaki drhajian@yahoo.com 100319475328460010013 100319475328460010013 Yes Social Determinant Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Behzad Heidari Bheidari6@gmail.com 100319475328460010014 100319475328460010014 No Mobility Impairment Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran Arefeh Hajian-Tilaki dr.arefehajian@yahoo.com 100319475328460010015 100319475328460010015 No Guilan University of Medical Sciences Alireza Firouzjahi Firouzjahi@yahoo.com 100319475328460010016 100319475328460010016 No Department of Orthodontics, Guilan University of Medical Sciences, Rasht, Iran Afsaneh Bakhtiari Bakhtiari@gmail.com 100319475328460010017 100319475328460010017 No Fatemeh Zahra Infertility and Reproductive Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran