en Gastroentrology Gastroentrology Original Article Original Article <p><span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Background: </em></strong></span>A decreased rate of successful <em>helicobacter pylori</em> (H.pylori) infection treatment has revealed serious demand for more effective regimens to eradicate infection. Therefore, probiotics have recently been considered to increase the rate of antibiotic regimens efficacy in <em>H. pylori</em> infections. In current randomized controlled trial, we evaluated the effect of double strain probiotic combination with standard triple therapy (STT), in the eradication rate of <em>H. pylori</em> infection.</span></span></p> <p><span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Methods:</em></strong></span> In current randomized placebo-control study, all patients (176 subjects) underwent the STT for 10 days. However, the study group received triple therapy for the eradication of <em>H. pylori</em> with supplement of <em>Lactobacillus</em> probiotic for 4 weeks and placebo was administered to control group, as well. Adverse effects of the antibiotic regimen were recorded for all patients. Six weeks after the cessation of probiotic intake, all patients underwent <em>H. Pylori</em> with fecal antigen of test, followed by a recurrence evaluation six months later.</span></span></p> <p><span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Results:</em></strong></span> There was no significant difference in demographic data and presenting symptoms between the study groups. The eradication rate of <em>H. pylori</em> infection was significantly higher in probiotic group (78.4%), compared to that of placebo group (64.8%) (P=0.033). In addition, adverse events were significantly less prevalent in patients that received probiotic (P=0.047). Nonetheless, there was no significant difference in terms of infection recurrence during a 6-month follow-up (P=0.07).</span></span></p> <p><span style="font-size:14px;"><span style="font-family:times new roman;"><span style="color:#0000FF;"><strong><em>Conclusion: </em></strong></span>Double strain probiotic in combination with STT increased the eradication rate of <em>H. pylori</em> infection, while the adverse events due to antibiotic therapy decreased</span></span></p> Helicobacter pylori, Standard triple therapy, Probiotic, Lactobacillus, Recurrence. 165 171 http://caspjim.com/browse.php?a_code=A-10-737-1&slc_lang=en&sid=1 Mehdi Haghdoost mehdihaghdoost@yahoo.com 10031947532846009233 10031947532846009233 No Department of Infectious Diseases, Tabriz University of Medical Sciences, Tabriz, Iran Sepehr Taghizadeh taghizadehs@tbzmed.ac.ir 10031947532846009234 10031947532846009234 No Department of Infectious Diseases, Tabriz University of Medical Sciences, Tabriz, Iran Majid Montazer Montazer55120@yahoo.com 10031947532846009235 10031947532846009235 No Department of Cardiothoracic Surgery, Tabriz University of Medical Sciences, Tabriz, Iran Parinaz Poorshahverdi Parinaz_ps@yahoo.com 10031947532846009236 10031947532846009236 No Department of Infectious Diseases, Tabriz University of Medical Sciences, Tabriz, Iran Ali Ramouz ali.ramouz@gmail.com 10031947532846009237 10031947532846009237 Yes Tabriz University of Medical Sciences, Tabriz, Iran Sanam Fakour 10031947532846009238 10031947532846009238 No Tabriz University of Medical Sciences, Tabriz, Ir