Babol University of Medical Sciences
Caspian Journal of Internal Medicine
2008-6164
2008-6172
12
3
2021
4
1
Serum zinc level and children`s asthma: A systematic and meta-analysis review article
236
242
EN
Javad
Ghaffari
Pediatric infectious diseases research center, Mazandaran University of Medical sciences, Sari, Iran
javadneg@yahoo.com
Y
0000-0002-1447-8916
Reza
Alizadeh-navaei
Gastrointestinal Cancer Research Center, Mazandarn University of Medical Sciences, Sari, Iran.
reza_nava@yahoo.com
N
0000-0003-0580-000X
Abbas
Dabaghzadeh
Pediatric infectious diseases research center, Mazandaran University of medical sciences, Sari, Iran
siamakdabaghzade@yahoo.com
N
0000-0003-1688-6849
Negar
Ghaffari
Pediatric infectious diseases research center, Mazandaran University of Medical sciences, Sari, Iran
negarghaffari@yahoo.com
N
0000-0000-0000-0000
10.22088/cjim.12.3.236
Background: Asthma is a chronic inflammatory respiratory disorder. Nutritional conditions affect allergic diseases such as asthma. The aim of this study was to review the serum zinc level in children with asthma.
Methods: This is a review article found in databases such as Google, PubMed, SID, Irandoc, Scopus and up-to-date. Key words for search included zinc, asthma, children and pediatric. There was no time limitation for the search. These articles on zinc levels in asthmatic children were meta-analyzed.
Results: Out of the 40 articles, 19 articles were excluded and 21 articles were included in this analysis. 15 articles evaluated serum zinc levels, 4 articles on hair zinc levels, one article evaluated nail zinc levels and another on zinc level in erythrocyte cells in children with asthma. Only 3 articles evaluated effects of zinc supplement treatment in children with asthma. Meta-analysis of studies showed that there was no significant difference between the standard mean differences of zinc level in asthmatic patients compared to the control group. We cannot analyze the association between zinc levels in hair and nail in children with asthma. All clinical trial studies show that zinc supplement improves clinical manifestations of asthma and patient’s pulmonary function test.
Conclusion: We found that the mean serum zinc level difference is not significant in children with asthma than healthy control group and it seems that there is no relation between mean serum zinc level and severity of asthma in children.
asthma, children, zinc, nutrition,
http://caspjim.com/article-1-2261-en.html
http://caspjim.com/article-1-2261-en.pdf
Babol University of Medical Sciences
Caspian Journal of Internal Medicine
2008-6164
2008-6172
12
3
2021
4
1
Heart involvement in transfusion-dependent beta-thalassemia with conventional echocardiography
243
248
EN
Hossein
Esfahani
Department of Pediatric Oncology, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
hesfehani@yahoo.com
N
0000-0002-2291-3412
Asadolah
Tanasan
Department of Pediatrics, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
asadolahtanasan@gmail.com
Y
0000-0002-6791-1875
Mina
Rezanejad
Department of Pediatrics, Besat Hospital, Hamadan University of Medical Sciences, Hamadan, Iran
minarezanejad53@gmail.com
N
0000-0002-2992-7606
Saadat
Torabian
Department of Epidemiology, Hamadan University of Medical Sciences, Hamadan, Iran
torabian_s@yahoo.com
N
0000-0002-4000-7691
10.22088/cjim.12.3.243
Background: The most important prognostic factor in transfusion-dependent beta-thalassemia is cardiac involvement, which is usually evaluated with echocardiography.
Methods: In this cross-sectional study (Aprill 2011 to Aprill 2012), conventional echocardiography was used to assess myocardial performance and valvular involvement (by trans-valvular Doppler study) for right and left heart abnormalities in transfusion-dependent beta-thalassemia.
Results: Among 60 patients, 43 cases had heart problems, that 26 (43.3%) of them had left myocardial dysfunction and 11 (18.3%) of them had right myocardial dysfunction, 3cases had both RV and LV myocardial dysfunction,(based on LVMPI & RVMPI, respectively). In patients with right myocardial dysfunction, 4 cases had pulmonary hypertension (PH) and 3 had both sided myocardial dysfunction. LVMPI and RVMPI were significantly increased in patients with cardiac involvement (p<0.001). Serum ferritin levels in patients with and without cardiac involvement were 2427±1788 ng/ml and 1573±592 ng/ml, respectively (p=0.008). All 4 patients who had PH, had been splenectomized. In splenectomized and non-splenectomized patients, LVMPI was 0.37 ± 0.11 and 0.38 ±0.1 (p = 0.589), RVMPI was 0.3±0.07 and 0.25±0.39 (p = 0.004), and TR gradient (TRG) was 28±11.8 mmHg and 19.7±5.2 mmHg (p = 0.033), respectively. Mean ferritin level in patients with a history of splenectomy (n=31), was 2525±1968 ng/ml and in patients without the history of splenectomy (n=29), it was 1821±947 ng/ml (p = 0.082).
Conclusion: In addition to left-sided heart involvement, conventional echocardiography revealed right-sided heart involvement in transfusion-dependent thalassemia patients that was not correlated with serum ferritin level.in splenectomized patients.
Beta Thalassemia, Blood Transfusion, Echocardiography, Heart.
http://caspjim.com/article-1-2312-en.html
http://caspjim.com/article-1-2312-en.pdf
Babol University of Medical Sciences
Caspian Journal of Internal Medicine
2008-6164
2008-6172
12
3
2021
4
1
Semi-surgical percutaneous dilatational tracheostomy vs. conventional percutaneous dilatational tracheostomy: A prospective randomized trial
249
255
EN
Novin
Nikbakhsh
Department of Surgery, Babol University of Medical Sciences, Babol, Iran
nikbakhsh.n@mubabol.ac.ir
N
0000-0002-6803-7358
Fatemeh
Amri
Student Research Committee, Babol University of Medical Sciences, Babol, Iran
rohanresearch88@gmail.com
N
0000-0000-0000-0000
Mahmood
Monadi
Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran
Dr.monadi@yahoo.com
N
0000-0002-5929-3042
Parviz
Amri
Clinical Research Development Unit of Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
pamrimaleh@gmail.com
Y
0000-0003-2648-9820
Ali
Bijani
Mobility Impairment Research Center, Babol University of Medical Sciences, Babol, Iran
drbijani@yahoo.com
N
0000-0003-2233-8726
10.22088/cjim.12.3.249
Background: Percutaneous dilatational tracheostomy (PDT) is a common surgical procedure in the ICU. The present study was conducted to compare semi-surgical percutaneous dilatational tracheostomy (SSPDT) with conventional percutaneous dilatational tracheostomy (CPDT).
Methods: The present randomized clinical trial was conducted on 160 patients hospitalized in the medical intensive care units (ICUs) with an indication for tracheostomy and were systematically divided into two equal groups of 80. In the CPDT group, after a small incision, a 16-gauge needle was blindly inserted into the trachea and the guidewire was placed inside the lumen. A stoma was created by passing a single dilator over the guidewire. In the SSPDT group, a transverse incision (2 cm) was made 1 cm below the cricoid, and the tracheal ring was then fully reached by releasing the subcutaneous tissues using the index figure, and PDT was then performed. The two groups were compared in terms of their tracheostomy complications (including bleeding, pneumothorax, stoma infection and accidental decannulation) and duration of the procedure.
Results: The two groups were homogeneous in terms of age, gender, mean APACHE score (P>0.05). There were no significant differences between the two groups in terms of the mean time from tracheal intubation to tracheostomy (P=0.869). The duration of the procedure was 5.16±1.72 minutes in the SSPDT group and 6.42±1.71 in the CPDT group (P<0.001). The complication rate was 7(8.75%) in the SSPDT group and 16(20%) in the CPDT group (P=0.043).
Conclusion: SSPDT is safer and has fewer complications than CPDT in ICU patients.
Intensive Care Unit, Percutaneous Dilatational Tracheostomy, Complications
http://caspjim.com/article-1-2041-en.html
http://caspjim.com/article-1-2041-en.pdf
Babol University of Medical Sciences
Caspian Journal of Internal Medicine
2008-6164
2008-6172
12
3
2021
4
1
Post-neoadjuvant chemoradiotherapy tumor resectability following induction chemotherapy in locally advanced proximal gastric and adenocarcinoma of the esophagogastric junction: A clinical trial
256
262
EN
Seyed Amir
Aledavood
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
aledavooda@mums.ac.ir
N
0000-0000-0000-0000
Kazem
Anvari
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AnvariK@mums.ac.ir
N
0000-0002-1080-1907
Soodabeh
Shahidsales
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
ShahidSalesS@mums.ac.ir
N
0000-0000-0000-0000
Sare
Hosseini
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
HosseiniS@mums.ac.ir
N
0000-0000-0000-0000
Ali
Emadi Torghabeh
Cancer Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
EmadiTA@mums.ac.ir
N
0000-0000-0000-0000
Masume
Masudian
Kosar Hospital, Semnan University of Medical Sciences, Semnan, Iran
masudian61@gmail.com
Y
0000-0000-0000-0000
10.22088/cjim.12.3.256
Background: Pre-operative chemoradiotherapy (NACRT) of patients with proximal gastric and esophagogastric junction (EGJ) adenocarcinoma may result in increased local control and improved patients’ survival rate. This study aimed to investigate the effect of NACRT on resectability of tumor in patients with proximal gastric and EGJ adenocarcinoma.
Methods: In this single-arm clinical trial, patients with locally advanced proximal gastric and EGJ adenocarcinoma were included. Two courses of paclitaxel/carboplatin chemotherapy alone followed by NACRT with a similar treatment regimen and a total radiation dose of 45-50.4/1.8-2 Grays were prescribed. After surgery, patients were evaluated for resection rate, pathologic response rate, and post-surgical complications.
Results: A total of 61 patients with a mean age of 65.9 years participated. Grades 1 and 2 were the most prevalent side effects, with grade 3 being the worst grade and exhibiting as leukopenia (4.9%) and thrombocytopenia (1.6%). 25 (41%) patients underwent surgery after NACRT. Post-surgery complication was reported in 20% of cases (including 8% mortality and 12% morbidity). R0 and R2 resection was observed in 88% and 12% of cases, respectively. Complete pathologic-response was achieved in 24% of patients.
Conclusion: Paclitaxel/carboplatin based neoadjuvant chemotherapy was associated with potential resectability and appropriate pathologic response in patients with locally advanced proximal gastric and EGJ adenocarcinoma. However, by reducing patient tolerance to complete courses of weekly chemotherapy, induction chemotherapy lowered the effectiveness of concurrent chemotherapy and radiotherapy (as a sensitizing agent). Hence, induction chemotherapy proved to be more unbeneficial causing delayed treatment and reducing concurrent chemoradiotherapy tolerance.
neoadjuvant chemoradiotherapy, proximal gastric adenocarcinoma, esophagogastric junction (EGJ) adenocarcinoma
http://caspjim.com/article-1-2382-en.html
http://caspjim.com/article-1-2382-en.pdf
Babol University of Medical Sciences
Caspian Journal of Internal Medicine
2008-6164
2008-6172
12
3
2021
4
1
Safety and efficacy of fingolimod in Iranian patients with relapsing-remitting multiple sclerosis: An open-label study
263
274
EN
Rozita
Doosti
Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Science, Tehran, Iran
rozita.doosti80@gmail.com
Y
0000-0001-9811-9154
Abdorreza
Naser Moghadasi
Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Science, Tehran, Iran
abdorrezamoghadasi@gmail.com
N
Amir Reza
Azimi
Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Science, Tehran, Iran
amirreza_azimi@yahoo.com
N
Shahrokh
Karbalai Saleh
Department of Cardiology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
Saleh6948@tums.ac.ir
N
0000-0002-7488-6188
Masoud
Etemadifar
Department of Functional Neurosurgery, Medical School, Isfahan University of medical science, Isfahan, Iran
adifar.1963@gmail.com
N
Vahid
Shaygannejad
Isfahan Neurosciences Research Center, Alzahra Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran
shaygannejad@med.mui.ac.ir
N
0000-0002-6226-0161
Fereshteh
Ashtari
Isfahan neuroscience research center, Isfahan University of Medical Sciences, kashani MS center, Isfahan, Iran
htari@med.mui.ac.ir
N
Mohammad Hossein
Harirchian
Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Imam Khomeini Hospital, Tehran, Iran
arirchn@hotmail.com
N
Bahaadin
Siroos
Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Imam Khomeini Hospital, Tehran, Iran
bsiroos@gmail.com
N
Hormoz
Ayramloo
Departments of Neurology, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran
uh@gmail.com
N
Nastaran
Majdinasab
Department of Neurology, Golestan Hospital, Ahwaz University of Medical Sciences, Iran
N.madjdinasab@gmail.com
N
0000-0001-5163-7210
Seyyed Mohammad Masood
Hojjati
Department of Neurology, Babol University of Medical Sciences, Babol, Iran
naser.moghadasi@yahoo.com
N
Nabiollah
Asghari
Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran
nbasghari@gmail.com
N
Seyed Mohammad
Baghbanian
Department of Neurology, Booalisina Hospital, Mazandaran University of Medical Sciences, Pasdaran Boulevard, Sari, Iran
sm.baghbanian@mazums.ac.ir.
N
0000-0002-8138-7504
Hamed
Cheraghmakani
Department of Neurology, Bu Ali Sina Hospital, Mazandaran University of Medical Sciences, Sari, Iran
akani@mazums.ac.ir
N
0000-0001-6583-3757
Mahmoud
Abedini
Department of Neurology, Mazandaran University of Medical Sciences, Sari, Iran
abedini@yahoo.com
N
Behnaz
Sedighi
Neurology Research Center, Kerman University of Medical Science, Kerman, Iran
behnaz.sedighi@gmail.com
N
0000-0002-4230-0955
Negar
Mohseni Abbas abadi
R;D Department, Osve Pharmaceutical Co., Tehran, Iran
mohseni@osvahpharma.com
N
Maedeh
Ghasemitabar
R;D Department, Osve Pharmaceutical Co., Tehran, Iran
ghasemi@osvahpharma.com
N
Sara
Talebianpour
R;D Department, Osve Pharmaceutical Co., Tehran, Iran
TalebiyanPour@osvahpharma.com
N
Tohid
Babayi Daylari
R;D Department, Osve Pharmaceutical Co., Tehran, Iran
T.babae@ut.ac.ir
N
Vahid
Dana
R;D Department, Osve Pharmaceutical Co., Tehran, Iran
Vahiddana@yahoo.com
N
Neda
Ghaleh noie
Quality Assurance Department, Osve Pharmaceutical Co., Tehran, Iran
Neda.ghalenoe@yahoo.com
N
Mohammad Ali
Sahraian
Multiple Sclerosis Research Center, Neuroscience Institute, Tehran University of Medical Science, Tehran, Iran
msahrai@sina.tums.ac.ir
N
0000-0002-3224-8807
10.22088/cjim.12.3.263
Background: Fingolimod was the first oral therapy approved for treating relapsing-remitting multiple sclerosis (RRMS) in 2010. This open-label study evaluated the safety and efficacy of fingolideR, 0.5 mg in Iranian MS patients during one-year follow-up.
Methods: A multicenter, open-label, longitudinal was designed to evaluate the safety and efficacy of fingolideR, 0.5 mg over a one-year follow-up period across 11 centers. The patients were visited by their neurologists every two months to evaluate possible adverse events and clinical disease activity considered by recording Kurtzke’s Expanded Disability Status Scale (EDSS).
Results: A total of 252 patients with the mean treatment duration of 343±45.70 days were. 20 patients experienced adverse events (AEs) and serious adverse events (SAEs) such as resistant urinary tract infection (UTI), premature atrial contraction (PAC), skin allergic reaction, macular edema, chicken pox, zona, panic attacks, and exacerbations associated with steroids treatment, all of which led to FingolideR discontinuation. The mean EDSS decreased from (2.15±1.29, 95%CI: 1.99to2.32) at baseline to (1.85±1.22, 95%CI: 1.68to2.02) at 12th month (final visit) while a p-value revealed significant differences comparing baseline and final EDSS (p<0.001). Mean annualized relapse rate (ARR) of the patients in one year prior to the study was (0.006±0.016, 95%CI: 0.004to0.008) which changed to (0.005±0.016, 95%CI: 0.003to0.007) at the end of the study period. Patients with a 12-month period of fingolideR treatment experienced sustained ARR and disease progression (p<0.001).
Conclusion: The obtained findings suggest that the administration of FingolideR, 0.5 mg (Fingolimod, Osvahpharma, Tehran, Iran) is safe and efficient for Iranian MS patients.
Fingolimod, Multiple Sclerosis, Safety, EDSS
http://caspjim.com/article-1-2280-en.html
http://caspjim.com/article-1-2280-en.pdf
Babol University of Medical Sciences
Caspian Journal of Internal Medicine
2008-6164
2008-6172
12
3
2021
4
1
Pattern of infectious diseases in northern Iran: An approach to internal medicine management
275
282
EN
Mohammad Ali
Jahani
Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
drmajahani@yahoo.com
N
0000-0003-0309-4172
Zohreh
Alinasab
Hospital administration Research Center, Sari Branch, Islamic Azad University, Sari, Iran
z.alinasab3820@gmail.com
N
0000-0001-9453-0659
Maysam
Rezapour
School of Nursing and Midwifery, Amol, Mazandaran University of Medical Sciences, Sari, Iran
drmajahani@yahoo.com
N
0000-0002-6039-3286
Melodi
Omrani Nava
Hospital administration Research Center, Sari Branch, Islamic Azad University, Sari, Iran
Melodyomraninava@yahoo.com
N
0000-0002-2322-6243
Ghahraman
Mahmoudi
Hospital Administration Research Center, Sari Branch, Islamic Azad University, Sari, Iran
Ghahraman48@yahoo.com
Y
0000-0003-3769-4379
10.22088/cjim.12.3.275
Background: Despite the development of their prevention and treatment, infectious diseases cause high mortality, many disabilities and inadequate living conditions worldwide. The aim of this study was to evaluate the pattern of infectious diseases in northern Iran with an approach to internal medicine management.
Methods: This cross-sectional research was conducted in 2019 on all 7095 infectious diseases patient records that referred to Ghaemshahr Razi Hospital, Mazandaran Province, Iran during 2012-2018. A checklist prepared by investigator was used to collect the data. The extracted data were coded and entered into SPSS 22 and analyzed using K2 and independent t-test at p<.05.
Results: The mean age of the study patients was 29.7±26.4. 4372 (61%) of the cases were males and the mean duration of hospitalization was 41.6±33.5. Age was significantly correlated to infectious diseases (P=.001). Gastroenteritis was the most common infectious disease among the men and women with 2442 (60.5%) and 1594 (39.47%), respectively. Based on the Pearson's correlation test, the relationship between leptospirosis, brucellosis, pulmonary tuberculosis, shigellosis, sepsis and infectious mononucleosis with gender, habitation, admission mode, discharged mode and age was significant (p<.05).
Conclusion: As the high frequent diseases were gastroenteritis, leptospirosis, brucellosis and sepsis and an increasing trend was in the prevalence of gastroenteritis, leptospirosis and lung tuberculosis, health system managers should consider training courses, preventive strategies, real-time interventions, increased hospital bed rate for patients with infectious diseases and so on.
Contagious, Infectious diseases, Disease process, Infectious
http://caspjim.com/article-1-2388-en.html
http://caspjim.com/article-1-2388-en.pdf
Babol University of Medical Sciences
Caspian Journal of Internal Medicine
2008-6164
2008-6172
12
3
2021
4
1
Cutaneous pseudolymphoma: A clinicopathological study and immunohistochemical patterns
283
289
EN
Fatemeh
Sari Aslani
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
sari_aslani_f@yahoo.com
Y
0000-0002-6232-9923
Mozhdeh
Sepaskhah
Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
sepaskhah_m@yahoo.com
N
0000-0002-8773-0019
Akbar
Safaei
Department of pathology, Shiraz University of Medical Sciences, Shiraz, Iran
safaeia@sums.ac.ir
N
0000-0002-2542-9861
Seddigheh
Jashounia Hormozi
Department of pathology, Shiraz University of Medical Sciences, Shiraz, Iran
dr.sd.hormozi@gmail.com
N
0000-0002-3886-1397
10.22088/cjim.12.3.283
Background: Cutaneous pseudolymphoma can histologically and clinically simulate various types of cutaneous lymphoma. We conducted the current study to evaluate the clinicopathological and immunohistochemical (IHC) aspects of cutaneous pseudolymphoma (PSL).
Methods: 30 cases of cutaneous PSL were selected from the archives of 2013-2017 in Shahid Faghihi Hospital pathology lab, Shiraz University of Medical Sciences. Available clinical data, histopathological features and IHC findings were statistically analyzed.
Results: The female: male ratio was 2:1 and the median age was 47±14.9 years. The lesions were located on the head and neck 26 (86.7%), trunk 2 (6.7%) and extremities 2 (6.7%). 23 (76.7%) cases had nodular pattern, while 7 (23.3%) showed diffuse pattern. The grenz zone was seen in 24 (80%) cases. Sixteen (53.3%) cases showed top heavy infiltration, 11 (36.7%) showed the same distribution of infiltration at the superficial and deep dermis, often involving the subcutaneous fat and 3(10%) showed bottom heavy infiltration. In IHC, 11(36.6%) cases showed the B cell type, 10 (33.3%) T cell type and 9 (30%) mixed type (B and T cells).
Conclusion: None of the cases was suspicious for cutaneous lymphoma, applying IHC staining. Gender distribution, and the site of cutaneous lesions were similar to previous studies. The most common histological subtype was nodular, while the B-cell cutaneous pseudolymphoma was slightly more common compared to the T-cell type.
Cutaneous, Pseudolymphoma, Immunohistochemistry.
http://caspjim.com/article-1-2097-en.html
http://caspjim.com/article-1-2097-en.pdf
Babol University of Medical Sciences
Caspian Journal of Internal Medicine
2008-6164
2008-6172
12
3
2021
4
1
Added diagnostic value of SPECT to evaluate bone metastases in breast cancer patients with normal whole body bone scan
290
293
EN
Seyed Mohammad
Abedi
1. Department of Radiology and Nuclear Medicine , Faculty of Medicine, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran
mabedi167@yahoo.com
N
Alireza
Mardanshahi
1. Department of Radiology and Nuclear Medicine , Faculty of Medicine, Cardiovascular Research Center, Mazandaran University of Medical Sciences, Sari, Iran
amardanshahi@yahoo.com
Y
0000-0001-7273-3068
Reza
Zeinali
Department of Radiology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
reza.zeinali@gmail.com
N
10.22088/cjim.12.3.290
Background: In this research, we aimed to survey the added value of single photon emission computed tomography (SPECT) in comparison with planar whole body bone scan to visualize bone metastatic lesions in patients with breast cancer.
Methods: A total of 80 patients with breast cancer (invasive ductal carcinoma) were examined with planar whole body bone scan and SPECT imaging using 99mTc-labelled methylene diphosphonate (99mTc-MDP). The patients with abnormal uptakes in SPECT imaging were also investigated with magnetic resonance imaging (MRI).
Results: Among these 80 patients with normal whole body bone SPECT scan, 19 (23.25%) of them revealed abnormal 99mTc-MDP uptake in skeleton. Furthermore, these 19 patients were subjected to MRI and 3 (3.75%) of them were confirmed with metastatic bone lesion.
Conclusion: The obtained data suggest that SPECT possess the added diagnostic over planar whole body bone scan.
99mTc-MDP, SPECT, whole body bone scan, breast cancer, bone metastasis
http://caspjim.com/article-1-2139-en.html
http://caspjim.com/article-1-2139-en.pdf
Babol University of Medical Sciences
Caspian Journal of Internal Medicine
2008-6164
2008-6172
12
3
2021
4
1
Hemostatic parameters in pulmonary tuberculosis patients after intensive phase treatment
294
298
EN
Lingga
Suryakusumah
Internal Medicine Department, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
linggasurya_dr@yahoo.com
Y
0000-0003-1572-1153
Nur Ahmad
Tabri
Division of Pulmonology and Respiratory, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
nurahmad_59@yahoo.co.id
N
0000-0003-0249-5671
Sahyuddin
Saleh
Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
udhin_ama@yahoo.com
N
0000-0002-6640-6762
Syakib
Bakri
Internal Medicine Department, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
syakibbakri@gmail.com
N
0000-0002-6615-5166
Hasyim
Kasim
Internal Medicine Department, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
hasyimkasim@yahoo.com
N
0000-0002-3261-2859
Andi Fachruddin
Benyamin
Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
andifach@med.unhas.ac.id
N
0000-0003-1811-0497
Erwin
Arief
Division of Pulmonology and Respiratory, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
erwin.pulmo@gmail.com
N
0000-0001-9600-4118
Arifin
Seweng
Biostatistics Department, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia
arifinsw@gmail.com
N
0000-0003-0853-7809
10.22088/cjim.12.3.294
Background: Tuberculosis (TB) is an infectious disease caused by mycobacterium tuberculosis (Mtb). This infection causes the release of proinflammatory cytokines that affect hemostasis. Pulmonary TB infection causes an increased activation of procoagulant factors, decreased anticoagulant factors and suppresses fibrinolysis which causes hypercoagulable. Our study is conducted to assess the association between pulmonary TB infection (PTB) with hemostatic parameters before and after intensive phase treatment.
Methods: This was an analytic observational prospective cohort design. The study was conducted at the Community Center for Lung Health in South Sulawesi. Studied subjects were recruited by consecutive sampling, in which the patients who met the inclusion criteria received intensive phase of ATD treatment. PT, aPTT, fibrinogen, and D-dimer were measured before treatment and after the intensive phase of ATD. These data were analyzed using the SPSS Version 22.
Results: In this study, 30 subjects are new cases of PTB. Prothrombin time, aPTT and D-dimer levels were higher in far advanced lesions and smear-positive sputum group (p<0.001). There was a significant level decrease in PT, aPTT, fibrinogen, D-dimer after intensive phase treatment (p<0.001).
Conclusion: Pulmonary tuberculosis infection is associated with hypercoagulability which is characterized by an increase in hemostatic parameters and has significant improvement after intensive phase of ATD treatment.
Pulmonary tuberculosis, Hemostatic parameters, Hypercoaguability
http://caspjim.com/article-1-2150-en.html
http://caspjim.com/article-1-2150-en.pdf
Babol University of Medical Sciences
Caspian Journal of Internal Medicine
2008-6164
2008-6172
12
3
2021
4
1
Effect of variability of central venous pressure values to prevent atrial fibrillation after coronary bypass grafting
299
306
EN
Seyed hossein
Hamidi
Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
s.hosseinhamidi@yahoo.com
Y
0000-0002-7542-7936
Ghasem
Faghanzadeh-ganji
Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
ghf.ganji@gmail.com
N
0000-0001-5220-9285
Ali
Baghaeian
Student Research Committee, Department of Obstetrics and Gynecology, Babol University of Medical Sciences, Babol, Iran
ali.baghaie63@gmail.com
N
0000-0000-0000-0000
Ali
Bijani
Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
alibijani@yahoo.com
N
0000-0003-2233-8726
Roghayeh
Pourkia
Clinical Research Development Unite of Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
r.pourkia@mubabol.ac.ir
N
0000-0002-8013-7888
10.22088/cjim.12.3.299
Background: Atrial fibrillation is an arrhythmia that results from abnormal depolarization of the atrium. Atrial fibrillation occurs in 5–40% of patients with cardiovascular bypass surgery, usually occurs on 2 to 4 days postoperatively. The aim of this study was Effect of variability of central venous pressure values to prevent atrial fibrillation after coronary bypass grafting.
Methods: The present clinical trial study was performed on 150 patients undergoing cardiac surgery referred to Ayatollah Rohani Hospital of Babol. Patients were divided into 3 groups, with normal range pressure (8 to 12 mmHg), low pressure (less than 8), high pressure (greater than 12) based on central venous pressure measurements. Patients were evaluated every 4 hours to 72 hours for central venous pressure, AF incidence and urine output. Finally, the data are analyzed by spss statistical software.
Results: In this study 79 (52.7%) patients were male and 71 (47.3%) were female. In examining changes in central venous pressure, the time effect also significantly increased central venous pressure. The results of independent t-test showed that the mean of central venous pressure changes in subjects with at day 16, second day at 16, 20, 24, third day at 4, 8, 12, 16, 20 and 24 hours Atrial fibrillation. Significantly more than those without atrialfibrillation (P<0.05).
Conclusion: In the study, central venous pressure changes the effect of time significantly increases the central venous pressure. Individuals with atrial fibrillation also had significantly greater central venous pressure changes than those without atrial fibrillation.
central venous pressure, atrial fibrillation, coronary by pass grafting
http://caspjim.com/article-1-2436-en.html
http://caspjim.com/article-1-2436-en.pdf
Babol University of Medical Sciences
Caspian Journal of Internal Medicine
2008-6164
2008-6172
12
3
2021
4
1
Diagnosis of frailty in geriatric patients: Is the pictorial fit frail scale an appropriate screening tool in hospital settings?
307
314
EN
Maryam
Chehrehgosha
Department of Gerontology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
chehrehgosha2008@gmail.com
N
0000-0001-9948-0371
Mahtab
Alizadeh-Khoei
Department of Clinical Gerontology & Geriatric, Medical School, Tehran University of Medical Sciences, Tehran, Iran
alizadeh.mahtab2020@gmail.com
N
0000-0001-9151-9016
Nasser
Behnampour
Department of Biostatistics and Epidemiology, Health Management and Social Development Research Center, Golestan University of Medical Sciences, Gorgan, Iran
behnampour.n@yahoo.com
N
0000-0003-1668-8922
Farshad
Sharifi
Elderly Health Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
shariifii@yahoo.com
N
0000-0002-2035-6587
Reza
Fadayevatan
Iranian Research Center of Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran
1092.reza@gmail.com
Y
0000-0002-9783-118X
Reyhaneh
Aminalroaya
Department of Geriatric, Ziaiyan Hospital, Medical School, Tehran University of Medical Sciences, Tehran, Iran
mary.kalantary@gmail.com
N
0000-0002-9016-4353
10.22088/cjim.12.3.307
Background: Frailty is accompanied by serious health complications in the elderly, especially during hospitalization. Visual scales have been designed for quick and easy evaluation of frailty in different cultures and settings. Therefore, this study aimed to define the accuracy of the Pictorial Fit Frail Scale (PFFS) for frailty screening in the hospitalized elderly in Iran.
Methods: This cross-sectional study was conducted on 304 hospitalized participants, aged 65-85 years old admitted at Ziaeian Hospital (Tehran) were enrolled through the inclusion criteria from August to December 2019. All participants were evaluated based on the Minimum Data Set-Home Care, the Pictorial Fit Frail Scale, and the Quality-of-Life instrument, through face-to-face interviews by a trained nurse at the admission time. Spearman’s correlation coefficient, and ROC analysis were performed using SPSS at p<0.05.
Results: The highest correlation was obtained by Frailty Index (FI) and PFFS (0.770). FI had a negative correlation with QoL (-0.48). The optimal cut-points for PFFS according to FI ≤ 0.08 (robust vs. pre-frail) was obtained 0.10 with sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy 100.00% and the best cut-point for PFFS based on FI ≥ 0.25 (pre-frail vs. frail) was obtained 0.29 with sensitivity and specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy 100.00%.
Conclusion: It seems the Pictorial Fit-Frail Scale (PFFS) is a reliable scale with a high level of accuracy, and excellent sensitivity and specificity to measure the frailty level in hospitalized elderlies.
Frailty, Pictorial Fit Frail Scale, MDS-specific frailty index, Hospital, Cut point, ROC
http://caspjim.com/article-1-2463-en.html
http://caspjim.com/article-1-2463-en.pdf
Babol University of Medical Sciences
Caspian Journal of Internal Medicine
2008-6164
2008-6172
12
3
2021
4
1
Evaluation of the developmental outcome in children with congenital hypothyroidism
315
322
EN
Razieh
Ehsani
Student Research Committee, Babol University of Medical Sciences, Babol, Iran
razieehsani66@gmail.com
N
0000-0002-1563-2516
Morteza
Alijanpour
Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
m.alijanpour@yahoo.com
Y
0000-0002-0031-4718
Mohammadreza
Salehiomran
The Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, Iran
salehiomran@yahoo.com
N
0000-0001-9323-1171
Farzan
Kheirkhah
Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
drfarzankh@yahoo.com
N
0000-0003-1420-5480
Leila
Moslemi
Health Reproductive Research Center, Sari Branch, Islamic Azad University, Sari, Iran
leilamoslemi116@yahoo.com
N
0000-0001-6350-399X
Faeze
Aghajanpour
Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
faezeaghajanpour@yahoo.com
N
0000-0002-1698-6906
10.22088/cjim.12.3.315
Background: Congenital hypothyroidism (CH) is one of the most common endocrine diseases and one of the major causes of mental retardation in children. So we aimed to evaluate the developmental outcome of children with CH.
Methods: This case-control study was performed on two 3-6-year-old groups of 100 patients. The case group was children with CH, referred to Endocrine Clinic of Amirkola Children's Hospital (2011-2017) and the control group was healthy children and normal from other states. The Denver developmental screening test-II (DDST_II) was used to assess the developmental factors and disorders in four areas of gross motor, fine motor, personal-social and language. Data were analyzed by SPSS 21 using descriptive statistics, t-test and chi-square, and a p<0.05 was considered significant.
Results: The mean age of 200 children in the case and control groups was 54.62±15.72 and 59.68±15.64 months, respectively. In the case group, 45% and 55% of them had transient and permanent CH, respectively. All four criteria of DDST_II in the control group as well as gross motor in the case group were normal, but fine motor, personal-social and language were reported normal in 94, 95 and 93% of the case group, respectively. All subjects with abnormal DDST_II, had a negative neonatal screening tests.
Conclusion: The results obtained from DDST_II indicated that 6% of children with CH had an abnormal development, all who had an onset of medical treatment over 30 days, which makes it important to screen the neonatal thyroid disease and diagnose this disease timely.
Developmental Outcome, Congenital Hypothyroidism, Pediatrics, Denver Developmental Screening Test II
http://caspjim.com/article-1-2390-en.html
http://caspjim.com/article-1-2390-en.pdf
Babol University of Medical Sciences
Caspian Journal of Internal Medicine
2008-6164
2008-6172
12
3
2021
4
1
High uric acid level increases the risk of acute kidney injury in acute coronary syndrome patients
323
326
EN
Erny
Puti
Division of Nephrology, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia
erny.puti87@gmail.com
Y
0000-0001-6610-7327
Haerani
Rasyid
Division of Nephrology, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia
haeraniabdurasyid@yahoo.com
N
0000-0001-7404-2973
Pendrik
Tandean
Division of Cardiology, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia
penrikt@yahoo.com
N
0000-0002-6600-4763
Himawan
Sanusi
Division of Endocrine Metabolic and Diabetes, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
wawan0404@yahoo.com
N
0000-0003-3828-2958
Hasyim
Kasim
Division of Nephrology, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia
hasyimkasim@yahoo.com
N
0000-0002-3261-2859
Syakib
Bakri
Division of Nephrology, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia
syakibbakri@gmail.com
N
0000-0002-1310-9721
Makbul
Aman
Division of Endocrine Metabolic and Diabetes, Department of Internal Medicine, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia
andimkb.aman@gmail.com
N
0000-0002-1310-9721
Arifin
Seweng
Biostatistics Department, Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia
arifinsw@gmail.com
N
0000-0003-0853-7809
10.22088/cjim.12.3.323
Background: Both clinical and experimental evidence have been published over the past few decades supporting the existence of a close relationship between the elevated levels of serum uric acid with cardiovascular events and acute kidney injury (AKI). This study aimed to determine the effect of serum uric acid levels on the incidence of AKI in acute coronary syndrome (ACS) patients.
Methods: A retrospective cohort study with a cross sectional design was performed. The research was conducted at Dr. Wahidin Sudirohusodo Hospital from October 2019 to December 2019. Nonrandom sampling was employed in the medical records. All patients who met the inclusion criteria were at > 18 years old and diagnosed with ACS with AKI. The demographic data of age, sex and serum uric acid levels were recorded. The data obtained were analyzed using the SPSS (Statistical Package for Social Sciences).
Results: There were 158 subjects of ACS patients with AKI and 135 without AKI. There was a significant correlation between high uric acid levels with the incidence of AKI in ACS (p<0.001). Patients with high serum uric acid levels were 9.5 times at risk of developing AKI compared to those with normal serum uric acid levels.
Conclusion: High uric acid level is one of the risk factors for AKI in ACS and indicates 9.5 times at risk of developing AKI compared to normal serum uric acid level. Therefore, it is necessary to monitor serum uric acid level and kidney function in ACS patients.
Acute kidney injury, Acute coronary syndrome, uric acid
http://caspjim.com/article-1-2217-en.html
http://caspjim.com/article-1-2217-en.pdf
Babol University of Medical Sciences
Caspian Journal of Internal Medicine
2008-6164
2008-6172
12
3
2021
4
1
Is there an independent association between metabolic syndrome and smoking in Iranian adults? Results of a large multicenter national survey
327
335
EN
Alipasha
Meysamie
Department of Preventive and Community Medicine, Tehran University of Medical Sciences, Tehran, Iran
meysamie@tums.ac.ir
N
0000-0003-4223-4254
Reza
Ghalehtaki
Radiation Oncology Research Center (RORC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
rezaght@gmail.com
N
0000-0003-1162-2019
Saeed
Ghodsi
Cardiovascular Research center, Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
dsaeedgh@gmail.com
Y
0000-0002-3079-0504
Mehrnaz
Mohebi
Cardiovascular Research center, Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
mohebi.mehrnaz@gmail.com
N
0000-0003-0685-590X
Shirin
Ghalehtaki
Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
sh.ghalehtaki@gmail.com
N
0000-0003-1288-6518
Fereshteh
Salarvand
Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran
F.salarvand89@gmail.com
N
0000-0001-8145-5784
Zahra
Hosseini
Cardiovascular Research center, Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
Zmed702@yahoo.com
N
0000-0003-0902-217X
Seyed-Ali
Sadre-Bafghi
Cardiovascular Research center, Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
aalissadr@gmail.com
N
0000-0003-3407-9899
10.22088/cjim.12.3.327
Background: Theoretically, smoking status should be associated with metabolic syndrome. This relationship has not been studied in Iranian population so far. This study aimed to explore the association among cigarette smoking, metabolic syndrome (MetS) and its domains in a nationally representative sample of Iranians aged 25-64.
Methods: Information of participants regarding demographic data and smoking habits gathered through WHO STEPS questionnaires in the frame of fourth national surveillance of the risk factors of non-communicable diseases in 2011 across the country. The fasting plasma glucose, triglyceride level, high-density lipoprotein cholesterol (HDL-C) level, blood pressure, and anthropometric indices in each patient were measured. Data of 4000 subjects were analyzed with complex sample survey method. The prevalence of metabolic syndrome was assessed according to two definitions: International Diabetes Federation (IDF) and Iranian definition.
Results: Herein, 38.4% of smoker participants and 36.6% of non-smokers met the IDF criteria for MetS (P=0.67). Similarly, 31.1% of smokers and 34.1% of non-smokers had MetS according to Iranian-IDF (P=0.427). Only in univariate analysis, using IDF criteria female smokers had lower prevalence of MetS than non-smokers (13.9% vs. 36.5%, P=0.01). Multivariate analysis determined the following odds ratios for the association of smoking with MetS defined by IDF and Iranian-IDF criteria, respectively: OR= 0.89 (0.53-1.47), P=0.638 and OR= 0.97 (0.59-1.58), P=0.901.
Conclusion: There was no significant association between smoking and MetS overall and among men. However, smoking was associated with lower prevalence of MetS among women.
Metabolic syndrome, Smoking, Adult, Complex Samples, Central Obesity, Prevalence, Risk factor, Iran
http://caspjim.com/article-1-1990-en.html
http://caspjim.com/article-1-1990-en.pdf
Babol University of Medical Sciences
Caspian Journal of Internal Medicine
2008-6164
2008-6172
12
3
2021
4
1
CavatermTM plus treatment in high – risk surgical patients
336
341
EN
Zinatossadat
Bouzari
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
z_b412003@yahoo.com
N
0000-0002-7456-9860
Ebrahim
Alijanpour
The Clinical Research Development Unite of Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran
dralijanpour@yahoo.com
N
0000-0001-6832-5774
shahla
yazdani
Fertility and Infertility Research Health Center, Health Research Institute, Babol of University of Medical Science, Babol, Iran
shahla_yazdani_1348@yahoo.com
N
0000-0002-1909-1446
Azita
Ghanbarpour
Fertility and Infertility Research Health Center, Health Research Institute, Babol of University of Medical Science, Babol, Iran
dr_ghanbarpour@yahoo.com
Y
0000-0001-7101-3261
Ali
Bijani
Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
ali_bizhani@yahoo.com
N
0000-0003-2233-8726
Tahereh Ashraf
Ganjoei
Department of Obstetrics and Gynecology, Preventative Gynecology Research Center (PGRC), Imam Hussein Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
rohanresearch88@gmail.com
N
0000-0000-0000-0000
hemmat
gholinia
Health Research Institute, Babol University of Medical Sciences, Babol, Iran
h_gholinia@yahoo.com
N
0000-0000-0000-0000
10.22088/cjim.12.3.336
Background: The purpose of the study was to evaluate the effectiveness and safety of thermal balloon ablation in women with high anesthetic and surgical risk compared to invulnerable women according to the American Society of Anesthesia (ASA) physical status stratification.
Methods: This report was based on a retrospective cohort study of women with heavy menstrual bleeding (HMB) who were eligible for treatment with CavatermTM plus during 2012-2017. Women were classified as high-risk (HR) or low-risk (LR) cohorts based on ASA physical status stratification. The primary outcome includes amenorrhea in the twelfth months after the treatment. Risk adjustments were performed using regression models.
Results: This research study consisted of 63 women with mean age 44.42±5.48. Mean of body mass index (BMI) in the HR cohort was higher than the LR cohort (31.48±6.22 vs 26.83± 3.51, P=0.005) and results were also similar considering the uterine length (mm) between HR and LR women (58.27±35.70 vs 30.92± 35.30, P=0.01). The primary outcome of treatment after a one-year follow-up in the two groups (HR and LR) was 31 (93.9%) and 15 (78.9%), respectively. After adjusting for known confounders including age, uterine length, parity, dysmenorrheal, the adjusted odds ratio was 0.94 (95% CI, 0.14– 2.5; P= 0.60).
Conclusion: For women with high anesthetic and surgical risks derived from serious underlying co morbidities, endometrial ablation can provide a minimally invasive, safe, and effective therapy for heavy menstrual bleeding.
Endometrial ablation, Menorrhagia, Amenorrhea, Recovery, Anesthesia, Obese women
http://caspjim.com/article-1-1606-en.html
http://caspjim.com/article-1-1606-en.pdf
Babol University of Medical Sciences
Caspian Journal of Internal Medicine
2008-6164
2008-6172
12
3
2021
4
1
Oral mucosa and Streptococcus mutans count in the saliva. Does graphene oxide nanoparticle mouthwash have a good effect?
342
349
EN
Fatemeh
Eshaghi Gorji
Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
fatima.eshaghi@yahoo.com
N
0000-0001-6624-7186
Maryam
Seyedmajidi
Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
ms_majidi79@yahoo.com
N
0000-0002-4671-4231
Fariba
Asgharpour
Department of Laboratory Sciences, Faculty of Para-medicine, Babol University of Medical Sciences, Babol, Iran
f_asgharpour@yahoo.com
N
0000-0001-6128-5407
Hamed
Tashakorian
Cellular and Molecular Biology Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
h.tashakkorian@gmail.com
N
0000-0002-2748-7440
Ali-akbar
Moghadamnia
Department of Pharmacology, School of Medicine, Babol University of Medical Sciences, Babol, Iran
moghadamnia@gmail.com
N
0000-0001-7140-1352
Sohrab
Kazemi
Neuroscience Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
kazemi.msm@gmail.com
N
0000-0002-8068-5745
Homayoon
Alaghehmand
1. Dental Materials Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
halagheh@yahoo.com
Y
0000-0002-5319-0309
10.22088/cjim.12.3.342
Background: This study aimed to assess the effect of graphene oxide (GO) nanoparticles mouthwash on oral mucosa, Streptococcus mutans (S. mutans) count in the saliva of rats, and human enamel surface microhardness, in comparison with fluoride mouthwash.
Methods: This study was conducted in two phases namely an animal study, and an in vitro experimental study. GO mouthwash (0.005%), sodium fluoride (NaF) mouthwash (0.05%), and a combination of both (0.05% NaF-0.005% GO) were prepared. The oral cavity of 36 rats was inoculated with S. mutans, and they were randomly divided into 4 groups according to the type of mouthwash. The control group received saline mouthwash. Fourteen days after using the mouthwashes, all rats were sacrificed, and the salivary S. mutans count was measured. The buccal and tongue mucosa were also histologically examined for the type and severity of inflammation, number of blood vessels, epithelial thickness, and epithelial keratinization. For microhardness testing, 40 sound extracted human premolars were randomly assigned to four groups (n=10) of culture medium with S. mutans and different mouthwashes. The enamel microhardness was measured at 7 and 14 days, and compared with the baseline value.
Results: The mean S. mutans count in the saliva of rats in GO and NaF-GO groups was significantly lower than that in other groups (p<0.001). Enamel microhardness in NaF and NaF-GO groups significantly increased at 7 and 14 days, compared with baseline.
Conclusion: Addition of GO nanoparticles improved the antibacterial properties without causing adverse mucosal effects such as ulceration, acute inflammation or atrophy of the epithelium of the oral mucosa, but had no effect on surface hardness of the enamel.
Nanoparticles, Streptococcus mutans, Sodium fluoride
http://caspjim.com/article-1-2606-en.html
http://caspjim.com/article-1-2606-en.pdf
Babol University of Medical Sciences
Caspian Journal of Internal Medicine
2008-6164
2008-6172
12
3
2021
4
1
Flow diverter-coil technique for endovascular treatment of complex wide neck brain aneurysms, Technical point
350
355
EN
Mohammad
Ghorbani
Neuroendovascular Division, Firouzgar Hospital, Iran University of Medical Sciences (IUMS), Tehran, Iran
mohghorbani@gmail.com
N
0000-0000-0000-0000
Ebrahim
Hejazian
Neuroendovascular Division, Ayatollah Rouhani Hospital, Babol University of Medical Sciences , Babol, Iran
sehbums@yahoo.com
Y
0000-0001-7383-4485
Eshagh
Bahrami
Department of neurosurgery, Rasool-e-Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
bahrami_eses@yahoo.com
N
0000-0000-0000-0000
Abolghasem
Mortazavi
Division of Vascular and Endovascular Neurosurgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran
sgmortazavi@gmail.com
N
0000-0000-0000-0000
Reza
Bahrami
Department of Neurosurgery, Tabriz University of Medical Sciences, Tabriz, Iran
Rbahrami1400@gmail.com
N
0000-0000-0000-0000
Nazila
Farnoush
Department of Surgery, Babol University of Medical Sciences, Babol, Iran
nazilafarnoush@gmail.com
N
0000-0000-0000-0000
10.22088/cjim.12.3.350
Background: Treatment of complex wide neck brain aneurysms is a challenging era in neurosurgery. Both surgical and endovascular therapies are considered for treatment of them. In endovascular, there are different ways such as trapping, coiling, stent and balloon assisted coiling. In this study, we use flow-diverter devices to create new vascular lumen and then coiling the aneurysm sac for three patients.
Methods: We describe three cases with complex cerebral aneurysm who were treated successfully by flow diverter-coil technique and point to technical nuances.
Results: In our patients, wide neck aneurysms, two in distal part of ICA (internal carotid artery) and other in basilar tip. We use flow-diverter-coil technique successfully. On the follow-up, aneurysms are treated completely without any complications.
Conclusion: We think flow diverter devices adjunct to coiling is a useful way for the treatment of complex wide neck cerebral aneurysms.
complex brain aneurysms, Flow diverters, coil, Treatment
http://caspjim.com/article-1-2340-en.html
http://caspjim.com/article-1-2340-en.pdf
Babol University of Medical Sciences
Caspian Journal of Internal Medicine
2008-6164
2008-6172
12
3
2021
4
1
Fluid Management in acute cardiac condition and superimposed COVID-19 infection. Do we need a careful revision?
356
358
EN
Mohammadreza
Naderian
Cardiovascular Research Institute, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
naderian-mr@razi.tums.ac.ir
N
0000-0003-1827-3173
Ali
Sheikhy
Cardiovascular Research Institute, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
a-sheikhy@student.tums.ac.ir
N
0000-0002-0358-4406
Seyed Mojtaba
Ghorashi
Cardiovascular Research Institute, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
mojtaba.ghorashi8@gmail.com
N
0000-0002-7933-5633
Masih
Tajdini
Cardiovascular Research Institute, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
drmasih84@yahoo.com
N
0000-0002-5286-9897
Saeed
Sadeghian
Cardiovascular Research Institute, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
k.vehhosseini@gmail.com
N
0000-0001-6817-1904
Kaveh
Hosseini
Cardiovascular Research Institute, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
k-hosseini@tums.ac.ir
Y
0000-0001-5676-3099
10.22088/cjim.12.3.356
COVID-19, Fluid management, Cardiac disease
http://caspjim.com/article-1-2512-en.html
http://caspjim.com/article-1-2512-en.pdf