Caspian Journal of Internal Medicine
Babol University of Medical Sciences
چهارشنبه 29 اسفند 1403
[Archive]
دوره 9، شماره 2 - ( 10-1396 )
جلد 9 شماره 2 صفحات 163-158 |
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Barzegari A, Mirdar S. Effect of a 12-week submaximal swimming training in rats exposed to tobacco- derived nitrosamine ketone. Caspian J Intern Med 2018; 9 (2) :158-163
URL: http://caspjim.com/article-1-1030-fa.html
URL: http://caspjim.com/article-1-1030-fa.html
Effect of a 12-week submaximal swimming training in rats exposed to tobacco- derived nitrosamine ketone. . 1396; 9 (2) :158-163
چکیده: (7485 مشاهده)
Background: Tobacco contains carcinogens such as NNK (nicotine-derived nitrosamine ketone) that makes induction of lung cancer by changing the stimulation of IL-10 expression. The aim of this study was to investigate changes in resting levels of IL-10 in lung tissues of rats exposed to NNK after a 12-week aerobic submaximal swimming training.
Methods: For this purpose, 46 Wistar rats were randomly divided into five groups consisting training, training + NNK, NNK, saline and control. NNK-induced groups received NNK subcutaneously one day per week at a rate of 12/5 mg per kg body weight and the training groups performed submaximal swimming training for 12 weeks. The levels of IL-10 in homogenized lung tissue were measured by ELISA.
Results: Findings indicated that a period of swimming training increased the IL-10 levels significantly in lung tissue of training group when compared to control (P=0.00) and NNK groups (P=0.00). Also, a significant increase of IL-10 level was observed in exercise + NNK group when compared to NNK group (p≤0/02). Furthermore, it was observed that IL-10 levels of NNK group had a significant decrease when compared to training group (P=0/00), training + NNK group (p≤0/02), but had insignificant increase when compared to saline group (p≤0/85).
Conclusions: Generally, it could be confirmed that regular submaximal aerobic training plays an important role in the inhibition of the effects of lung inflammation induced by NNK via increasing IL-10 activity.
Methods: For this purpose, 46 Wistar rats were randomly divided into five groups consisting training, training + NNK, NNK, saline and control. NNK-induced groups received NNK subcutaneously one day per week at a rate of 12/5 mg per kg body weight and the training groups performed submaximal swimming training for 12 weeks. The levels of IL-10 in homogenized lung tissue were measured by ELISA.
Results: Findings indicated that a period of swimming training increased the IL-10 levels significantly in lung tissue of training group when compared to control (P=0.00) and NNK groups (P=0.00). Also, a significant increase of IL-10 level was observed in exercise + NNK group when compared to NNK group (p≤0/02). Furthermore, it was observed that IL-10 levels of NNK group had a significant decrease when compared to training group (P=0/00), training + NNK group (p≤0/02), but had insignificant increase when compared to saline group (p≤0/85).
Conclusions: Generally, it could be confirmed that regular submaximal aerobic training plays an important role in the inhibition of the effects of lung inflammation induced by NNK via increasing IL-10 activity.
نوع مطالعه: Original Article |
موضوع مقاله:
Pathology
دریافت: 1396/1/31 | پذیرش: 1396/3/20 | انتشار: 1396/10/19
دریافت: 1396/1/31 | پذیرش: 1396/3/20 | انتشار: 1396/10/19
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