Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Wed, Mar 19, 2025
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Volume 15, Issue 4 (Autumn 2024)
Caspian J Intern Med 2024, 15(4): 623-628 |
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Barzegar A, Alijanpour M, Esmaeeli M, Khafri S, Nooreddini H G, Pournasrollah M et al . Thyroid function tests in overweight and obese children and adolescents with and without non-alcoholic fatty liver disease. Caspian J Intern Med 2024; 15 (4) :623-628
URL: http://caspjim.com/article-1-4019-en.html
URL: http://caspjim.com/article-1-4019-en.html
Armineh Barzegar 
, Morteza Alijanpour * , Mohammadreza Esmaeeli , Soraya Khafri , Haj Ghorban Nooreddini , Mohammad Pournasrollah , Pouria Alijanpour
, Morteza Alijanpour * , Mohammadreza Esmaeeli , Soraya Khafri , Haj Ghorban Nooreddini , Mohammad Pournasrollah , Pouria Alijanpour
Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, IR Iran. , m.alijanpour@yahoo.com
Abstract: (929 Views)
Background: Hypothyroidism can play an important role in the development of non-alcoholic fatty liver disease (NAFLD). This study compared the thyroid function tests in overweight and obese children and adolescents with and without NAFLD.
Methods: This case-control study was conducted on 100 children and adolescents aged 4-18 years who referred to the endocrinology clinic of Amirkola Children's Hospital, Babol, Iran in 2021. 42 obese and overweight children with NAFLD were considered as case group and 56 persons without NAFLD as control group. They were selected after physical examination and body mass index (BMI) assessment. Then, TSH, T4, FBS, lipid profile, 25(OH) vit D3 (VD), AST and ALT levels were measured. Abdominal ultrasound was performed to survey fatty liver. T-test and Chi-score were used for analysis and p< 0.05 was considered significant.
Results: The mean age in both group was 11.63±2.55 and 10.07±2.61 years, respectively (P=0.004). Hypothyroidism was not seen in the groups. Two groups in terms of mean TSH (P=0.92), T4 (P=0.87), FBS (P=0.33), cholesterol (P=0.44), LDL (P=0.35), VD (P=0.07) had no significant difference. However, difference was found between the two groups in terms of the mean level of AST (P=0.003), ALT (P=0.001), TG (P=0.02), HDL (P=0.01) and BMI (P<0.001).
Conclusion: This study showed that the mean level of thyroid hormones in both groups did not have significant difference and hypothyroidism was not seen. Other studies with larger sample size and longer periods of time are suggested.
Methods: This case-control study was conducted on 100 children and adolescents aged 4-18 years who referred to the endocrinology clinic of Amirkola Children's Hospital, Babol, Iran in 2021. 42 obese and overweight children with NAFLD were considered as case group and 56 persons without NAFLD as control group. They were selected after physical examination and body mass index (BMI) assessment. Then, TSH, T4, FBS, lipid profile, 25(OH) vit D3 (VD), AST and ALT levels were measured. Abdominal ultrasound was performed to survey fatty liver. T-test and Chi-score were used for analysis and p< 0.05 was considered significant.
Results: The mean age in both group was 11.63±2.55 and 10.07±2.61 years, respectively (P=0.004). Hypothyroidism was not seen in the groups. Two groups in terms of mean TSH (P=0.92), T4 (P=0.87), FBS (P=0.33), cholesterol (P=0.44), LDL (P=0.35), VD (P=0.07) had no significant difference. However, difference was found between the two groups in terms of the mean level of AST (P=0.003), ALT (P=0.001), TG (P=0.02), HDL (P=0.01) and BMI (P<0.001).
Conclusion: This study showed that the mean level of thyroid hormones in both groups did not have significant difference and hypothyroidism was not seen. Other studies with larger sample size and longer periods of time are suggested.
Type of Study: Original Article |
Subject:
Endocrinology
Received: 2023/07/19 | Accepted: 2023/12/27 | Published: 2024/08/29
Received: 2023/07/19 | Accepted: 2023/12/27 | Published: 2024/08/29
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