دوره 7، شماره 2 - ( 1-1395 )                   جلد 7 شماره 2 صفحات 135-133 | برگشت به فهرست نسخه ها

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Fallah F, Hamidikenari A, Sajadi S N, Sajadi S R, Shiran M R. Influence of methadone on clopidogrel in addicts on methadone maintenance therapy. Caspian J Intern Med 2016; 7 (2) :133-135
URL: http://caspjim.com/article-1-418-fa.html
Influence of methadone on clopidogrel in addicts on methadone maintenance therapy. . 1395; 7 (2) :133-135

URL: http://caspjim.com/article-1-418-fa.html


چکیده:   (7450 مشاهده)

Background: Clopidogrel is a prodrug that converts in the liver to an active thiol metabolite, which irreversibly inhibits the platelet P2Y12 adenosine diphosphate receptor. It seems that methadone as CYP2C19 inhibitor affects ticlopidine activity in vivo. This study aimed to test the ability of methadone in changing ticlopidine pharmacokinetics.

Methods: We conducted a case–control study in 10 subjects. The cases (5 subjects) in our study were addicts who were receiving methadone maintenance treatment (MMT) for preventing opium withdrawal symptoms.  The control group were opiate users before starting MMT. In both groups, the patients received clopidogrel (75mg/day) for 5 days. On the 6th day, the subjects returned to the clinic, blood samples were taken up to 12 hours following clopidogrel dosing in case and  control groups. Plasma concentration of clopidogrel was measured by GC-MAS. Noncompartmental pharmacokinetic analysis was performed using Microsoft Excel software to estimate PK parameters.

Results: In this study, methadone decreased clopidogrel clearance by 25% and increased the AUC0-inf nearly 1.3 fold during the coadministration of clopidogrel as an antiplatelet drug.

Conclusion: A significant decrease in the clearance of clopidogrel during the coadministration of methadone consistent with a decrease in clopidogrel conversion to its active metabolite and this may decrease its efficacy and may have life-threatening consequences for the patients undergoing clopidogerel maintenance therapy

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نوع مطالعه: Original Article | موضوع مقاله: pharmacology
دریافت: 1393/7/21 | پذیرش: 1394/6/24 | انتشار: 1394/12/24

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