Caspian Journal of Internal Medicine
Babol University of Medical Sciences
چهارشنبه 6 خرداد 1405
[Archive]
دوره 17، شماره 2 - ( 1-1405 )
جلد 17 شماره 2 صفحات 0-15 |
برگشت به فهرست نسخه ها
Ethics code: IR.UMSU.REC.1400.034
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Sadri M, Masudi S, Farshid S, Nemati Oskuii M. The correlation between survival with clinical and pathological features of renal cancer patients after surgical intervention. Caspian J Intern Med 2026; 17 (2) :15-0
URL: http://caspjim.com/article-1-4600-fa.html
URL: http://caspjim.com/article-1-4600-fa.html
The correlation between survival with clinical and pathological features of renal cancer patients after surgical intervention. . 1405; 17 (2) :15-0
چکیده: (63 مشاهده)
Background: Renal cell carcinoma (RCC) is a prevalent malignancy with a steadily increasing incidence. This study examined the association between clinical and pathological factors and RCC patient survival outcomes.
Methods: This cross-sectional study enrolled patients diagnosed with malignant renal tumors who underwent surgical resection at Urmia Imam Khomeini Hospital between April 2017 and March 2022. Eligible patients were identified through a review of medical records and recruited using a convenience sampling method. Demographic, clinical, and pathological data were collected for each patient.
Results: Of the 171 patients, 104 were male and 67 were female with a mean age of 57.9 years (SD ±14.5). The one-, three, and five-year overall survival rates were 84.7%, 72.4%, and 70.5%, respectively. Univariate regression analysis revealed that five-year mortality following surgical intervention was strongly associated with moderate-to-severe anemia (HR 15.661, 95% CI 6.880-35.651, p < 0.001), elevated ESR (>50; HR 14.172, 95% CI 5.370-37.404, p < 0.001), presence of necrosis (HR 13.216, 95% CI 5.213-33.509, p < 0.001), and lymphovascular invasion (HR 7.988, 95% CI 4.184-15.251, p < 0.001). Multivariate regression analysis identified moderate-to-severe anemia, lymphovascular invasion, and large tumor size as strong predictors of five-year mortality. Conversely, the absence of anemia, lymphovascular invasion, and smaller tumor size (<6 cm) were associated with a lower mortality risk and improved survival. Overweight and obese patients exhibited a lower risk of mortality.
Conclusion: These findings highlight the importance of considering clinical and pathological features in the management and prognosis of RCC patients.
Methods: This cross-sectional study enrolled patients diagnosed with malignant renal tumors who underwent surgical resection at Urmia Imam Khomeini Hospital between April 2017 and March 2022. Eligible patients were identified through a review of medical records and recruited using a convenience sampling method. Demographic, clinical, and pathological data were collected for each patient.
Results: Of the 171 patients, 104 were male and 67 were female with a mean age of 57.9 years (SD ±14.5). The one-, three, and five-year overall survival rates were 84.7%, 72.4%, and 70.5%, respectively. Univariate regression analysis revealed that five-year mortality following surgical intervention was strongly associated with moderate-to-severe anemia (HR 15.661, 95% CI 6.880-35.651, p < 0.001), elevated ESR (>50; HR 14.172, 95% CI 5.370-37.404, p < 0.001), presence of necrosis (HR 13.216, 95% CI 5.213-33.509, p < 0.001), and lymphovascular invasion (HR 7.988, 95% CI 4.184-15.251, p < 0.001). Multivariate regression analysis identified moderate-to-severe anemia, lymphovascular invasion, and large tumor size as strong predictors of five-year mortality. Conversely, the absence of anemia, lymphovascular invasion, and smaller tumor size (<6 cm) were associated with a lower mortality risk and improved survival. Overweight and obese patients exhibited a lower risk of mortality.
Conclusion: These findings highlight the importance of considering clinical and pathological features in the management and prognosis of RCC patients.
نوع مطالعه: Original Article |
موضوع مقاله:
Nephrology
دریافت: 1403/9/8 | پذیرش: 1404/6/31 | انتشار: 1405/1/4
دریافت: 1403/9/8 | پذیرش: 1404/6/31 | انتشار: 1405/1/4
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