Caspian Journal of Internal Medicine
Babol University of Medical Sciences
شنبه 21 شهریور 1405
[Archive]
دوره 17، شماره 3 - ( 3-1405 )
جلد 17 شماره 3 صفحات 677-671 |
برگشت به فهرست نسخه ها
Ethics code: IR.ARAKMU.REC.1400.228
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Hosseinzadeh M, Shirvandehi M M, Sehat N, Moslemi A, Ghaznavi-Rad E, Khansarinejad B, et al . Hormonal Dysregulation in COVID-19: A Comparative Analysis of Cortisol, Growth Hormone, and IGF-1 Levels Across Different Severities of Illness. Caspian J Intern Med 2026; 17 (3) :671-677
URL: http://caspjim.com/article-1-4939-fa.html
URL: http://caspjim.com/article-1-4939-fa.html
Hormonal Dysregulation in COVID-19: A Comparative Analysis of Cortisol, Growth Hormone, and IGF-1 Levels Across Different Severities of Illness. . 1405; 17 (3) :671-677
چکیده: (8 مشاهده)
Background: COVID-19 has multiple effects on the endocrine system, particularly altering the levels of growth hormone (GH), insulin-like growth factor-1 (IGF-1), and cortisol, which may influence disease severity and prognosis. This study aimed to evaluate circulating levels of GH, IGF-1, and cortisol in COVID-19 patients categorized by disease severity, including outpatients, inpatients, and intensive care unit (ICU) patients.
Methods: A total of 118 confirmed COVID-19 patients were divided into three groups: outpatients, inpatients, and ICU patients. Serum levels of GH, IGF-1, and cortisol were measured using ELISA and statistically compared across groups. Correlations among these hormones were also analyzed.
Results: Cortisol levels were highest in inpatients, intermediate in ICU patients, and lowest in outpatients. GH levels were reduced in ICU patients compared to other groups, with no difference between inpatients and outpatients. IGF-1 levels were highest in outpatients, followed by inpatients, and lowest in ICU patients. A significant inverse correlation between cortisol and IGF-1 was observed only in ICU patients (p = 0.013).
Conclusion: COVID-19 severity is associated with dysregulation of GH, IGF-1, and cortisol. The inverse cortisol–IGF-1 correlation in ICU patients suggests the impact of physiological stress on hormonal imbalance and impaired recovery. Endocrine interventions may improve clinical outcomes in severe cases.
Methods: A total of 118 confirmed COVID-19 patients were divided into three groups: outpatients, inpatients, and ICU patients. Serum levels of GH, IGF-1, and cortisol were measured using ELISA and statistically compared across groups. Correlations among these hormones were also analyzed.
Results: Cortisol levels were highest in inpatients, intermediate in ICU patients, and lowest in outpatients. GH levels were reduced in ICU patients compared to other groups, with no difference between inpatients and outpatients. IGF-1 levels were highest in outpatients, followed by inpatients, and lowest in ICU patients. A significant inverse correlation between cortisol and IGF-1 was observed only in ICU patients (p = 0.013).
Conclusion: COVID-19 severity is associated with dysregulation of GH, IGF-1, and cortisol. The inverse cortisol–IGF-1 correlation in ICU patients suggests the impact of physiological stress on hormonal imbalance and impaired recovery. Endocrine interventions may improve clinical outcomes in severe cases.
نوع مطالعه: Original Article |
موضوع مقاله:
Infectious Diseases
دریافت: 1404/7/15 | پذیرش: 1405/2/1 | انتشار: 1405/3/19
دریافت: 1404/7/15 | پذیرش: 1405/2/1 | انتشار: 1405/3/19
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