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:: Volume 12, Issue 2 (3-2021) ::
Caspian J Intern Med 2021, 12(2): 124-128 Back to browse issues page
The Role of microRNA in Cancer Cachexia and Muscle Wasting: A Review Article
Noorwati Sutandyo *
Hematology and Medical Oncology Division, Dharmais National Cancer Centre Hospital, Jakarta, Indonesia , noorwatisoetandyo@gmail.com
Abstract:   (980 Views)
Almost half of cancer patients experience cachexia syndrome. Cachexic patients are at risk of increased side effects of chemotherapy, reduced tolerance to chemotherapy drugs, longer duration of treatment period, and decreased quality of life. Cancer cachexia is a multifactorial syndrome. Micro ribonucleic acid (miRNA), a “non-coding RNA”, is considered to be a risk factor of cachexia and muscle wasting in cancer patients. miRNA has a role in affecting protein regulation, associated with different inflammatory and disease pathways. miRNA can also affect cytokines or directly change the regulation of metabolism that lead to cachexia. In this review, we want to focus on the pathophysiology to give a better understanding about the role of miRNA in the development of cancer cachexia. Based on various pathways of miRNA in cancer cachexia, it can be a potential target for therapeutic strategies. Improved knowledge about miRNA can give the opportunity to develop new treatment in the management of cancer cachexia.
Keywords: micro RNA, cancer, cachexia, muscle wasting
Full-Text [PDF 184 kb]   (259 Downloads)    
Type of Study: Review Article | Subject: Oncology
Received: 2020/01/20 | Accepted: 2020/07/27 | Published: 2021/03/20
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Sutandyo N. The Role of microRNA in Cancer Cachexia and Muscle Wasting: A Review Article. Caspian J Intern Med. 2021; 12 (2) :124-128
URL: http://caspjim.com/article-1-2181-en.html

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Volume 12, Issue 2 (3-2021) Back to browse issues page
Caspian Journal of Internal Medicine
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