Caspian Journal of Internal Medicine
Babol University of Medical Sciences
Fri, Aug 16, 2024
[Archive]
Volume 9, Issue 3 (5-2018)
Caspian J Intern Med 2018, 9(3): 220-227 |
Back to browse issues page
Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Kheirkhah F, Tayyebi G, Rabiee S M, Moghadamnia A, Bijani A. Efficacy of different doses of ketamine as a bolus in major depressive disorder. Caspian J Intern Med 2018; 9 (3) :220-227
URL: http://caspjim.com/article-1-1012-en.html
URL: http://caspjim.com/article-1-1012-en.html
Student Research Committee, Babol University of Medical Sciences, Babol, Iran , g.tayyebi@yahoo.com
Abstract: (6235 Views)
Background: Major depressive disorder is a severe, heterogeneous, common medical illness and a leading cause of disability throughout the world that poses a significant public health issue. Previous studies have shown rapid antidepressant effects following a single administration of ketamine. This study aimed to assess the impact of route of administration and dose of ketamine for the reduction of depressive symptoms and compare the effects of different doses and methods.
Methods: A double-blind clinical controlled trial was done on 100 patients with a primary diagnosis of major depressive disorder who were assigned into two groups of 50 subjects at a dose of 0.5 mg/kg and 0.75 mg/kg ketamine and each group was divided into two groups of 25 subjects following a single dose of intravenous bolus and infusion of ketamine. The patient’s severity of depression was evaluated with Hamillton Depression Rating Scale and Beck Depression Inventory scores after 2 days, 7 days, 30 days and 60 days of ketamine administration, then the results were compared between groups.
Results: According to Hamilton and Beck score, the treatment response in investigated patients was 64% and 60%, respectively.
Conclusions: These data suggest that ketamine effect is related to drug dose and type of administration. The dose of 0.75 mg/kg of ketamine is more effective than 0.5 mg/kg and a bolus injection of low-dose ketamine (0.5 mg/kg) is more effective than infusion and in high-dose ketamine (0.75 mg/kg), there was no difference between the methods of drug administration.
Methods: A double-blind clinical controlled trial was done on 100 patients with a primary diagnosis of major depressive disorder who were assigned into two groups of 50 subjects at a dose of 0.5 mg/kg and 0.75 mg/kg ketamine and each group was divided into two groups of 25 subjects following a single dose of intravenous bolus and infusion of ketamine. The patient’s severity of depression was evaluated with Hamillton Depression Rating Scale and Beck Depression Inventory scores after 2 days, 7 days, 30 days and 60 days of ketamine administration, then the results were compared between groups.
Results: According to Hamilton and Beck score, the treatment response in investigated patients was 64% and 60%, respectively.
Conclusions: These data suggest that ketamine effect is related to drug dose and type of administration. The dose of 0.75 mg/kg of ketamine is more effective than 0.5 mg/kg and a bolus injection of low-dose ketamine (0.5 mg/kg) is more effective than infusion and in high-dose ketamine (0.75 mg/kg), there was no difference between the methods of drug administration.
Type of Study: Original Article |
Subject:
psychiatry
Received: 2017/04/5 | Accepted: 2017/10/30 | Published: 2018/05/8
Received: 2017/04/5 | Accepted: 2017/10/30 | Published: 2018/05/8
Send email to the article author
| Rights and permissions | |
 |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |
