[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 9, Issue 4 (9-2018) ::
Caspian J Intern Med 2018, 9(4): 334-340 Back to browse issues page
Clinical profile and predictors of Severe Dengue disease : A study from South India
Vijay Kumar Agrawal , Saroj Kumar Prusty , Ch Santosh Reddy , Gangireddy Krishna Mohan Reddy , Rakesh Kumar Agrawal , VCS Srinivasarao Bandaru
Department of Research, Yashoda Hospital, Hyderabad, India , rsbhandaru@gmail.com
Abstract:   (479 Views)
Background: Dengue is endemic and prevalent in tropical and sub-tropical countries including India and can cause significant mortality and morbidity. There are limited studies available on factors associated with severe dengue from India, to investigate the predictors of severe dengue in south Indian patients.
Methods: We recruited 334 patients with dengue admitted in Yashoda Hospital, Hyderabad. Study period was between March 2015 and February 2017. Based on clinical symptoms, we divided patients into severe dengue and non-severe dengue. Univariate and multivariate analysis was performed for prognostic factors of severe dengue.
Results: Out of 334 patients, there were 186(55.6%) males with mean age 30.3±14.3 39 years (age range: 10-73 years), severe dengue was seen in 117(35%) and non-severe dengue in 217(65%). Clinical symptoms of diabetes, low platelet count (<50,000mm3), melena, skin rash, delayed admission (>5days after onset) elevated hematocrit, lymphadenopathy, hepatomegaly, splenomegaly, convulsions and mortality were significantly associated with severe dengue. After multivariate analysis, diabetes (OR: 2.12; 95% CI:1.34-4.65) (<0.0001), elevated hematocrit (OR: 3.14; 95% CI:2.17-6.14) (<0.0001), skin rashes (OR: 1.99; 95% CI: 1.11-3.55) (<0.0001), melena (OR: 2.59; 95% CI:1.40-4.93) (<0.0001),  low platelet count (OR: 6.71; 95% CI:4.12-13.6) (<0.0001), lymphadenopathy (OR: 3.12 95% CI: 1.91-7.85) (<0.0001) and delayed admission (OR: 2.40; 95% CI:1.31-3.41) (<0.0001) were significantly associated with severe dengue disease.
Conclusions: In our study, it was established that low platelet count, elevated hematocrit, diabetes, skin rash, melena, lymphadenopathy and delayed in admission (>5days) were independently associated with severe dengue.
Keywords: clinical manifestation and laboratory test, and delayed in admission severe dengue disease.
Full-Text [PDF 279 kb]   (53 Downloads)    
Type of Study: Original Article | Subject: Infectious Diseases
Received: 2017/09/24 | Accepted: 2018/03/5 | Published: 2018/10/1
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Agrawal V K, Prusty S K, Reddy C S, Krishna Mohan Reddy G, Agrawal R K, Bandaru V S. Clinical profile and predictors of Severe Dengue disease : A study from South India. Caspian J Intern Med. 2018; 9 (4) :334-340
URL: http://caspjim.com/article-1-1219-en.html


Volume 9, Issue 4 (9-2018) Back to browse issues page
Caspian Journal of Internal Medicine
Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 3781