[صفحه اصلی ]   [Archive]  
:: صفحه اصلي :: درباره نشريه :: آخرين شماره :: تمام شماره‌ها :: جستجو :: ثبت نام :: ارسال مقاله :: تماس با ما ::
:: دوره 9، شماره 4 - ( 6-1397 ) ::
جلد 9 شماره 4 صفحات 393-396 برگشت به فهرست نسخه ها
Spontaneous relapse in patients with inactive chronic hepatitis B virus infection
چکیده:   (144 مشاهده)

Background: Chronic hepatitis B virus infection (HBV) may reactivate during the course of the disease and is called spontaneous relapse. The purpose of this study was to evaluate the incidence of relapse of hepatitis in subjects with inactive HBV carriers.
Methods: This follow-up study was performed on 785 patients with inactive HBV carriers that were followed-up at six month intervals. The presence of serum HBsAg and anti-HBe, without HBeAg, HBV DNA levels <2000 IU/ml with normal alanine aminotransferase (ALT) levels was defined as inactive carriers. Patients who developed ALT ≥80 IU/L with HBV DNA levels ≥2000 IU/ml were considered as spontaneous relapse.
Results: Seven hundred- eighty five cases (441 males, 344 females) of chronic HBV infected individuals were followed-up. The mean age at the entrance of the study was 30.5±11.8 years. The mean follow-up duration was 5.9±5 years. Relapse was seen in 35 (4.5%) cases,  in 27 out of 441 (6.1%) males and in 8 out of 344 (2.3%) females and in 4.2% subjects ≥ 30 years versus in 4.7% cases of under 30 years (p>0.05). The development of relapse in males was higher than females (hazard ratio 2.53, 95% CI 1.2-5.6, p=0.021), but age ≥30 or < 30 years did not have effect (hazard ratio1.21, 95% CI 0.62-2.36, p=0.58).
Conclusions: The results show that spontaneous relapse of hepatitis may develop during the course of chronic HBV infection. We suggest that all patients with chronic hepatitis B, regardless of their age, be examined for the possibility of relapse.

متن کامل [PDF 283 kb]   (51 دریافت)    
نوع مطالعه: Original Article | موضوع مقاله: Infectious Diseases
دریافت: ۱۳۹۶/۱/۲۸ | پذیرش: ۱۳۹۷/۶/۳۱ | انتشار: ۱۳۹۷/۷/۹
ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

CAPTCHA code



XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Karajibani M, Hasanjani-roushan M, bayani M, Javanian M, Bijani A, Masrour-Roudsari J. Spontaneous relapse in patients with inactive chronic hepatitis B virus infection. Caspian J Intern Med. 2018; 9 (4) :393-396
URL: http://caspjim.com/article-1-1026-fa.html

Spontaneous relapse in patients with inactive chronic hepatitis B virus infection. 1. 1397; 9 (4) :393-396

URL: http://caspjim.com/article-1-1026-fa.html



دوره 9، شماره 4 - ( 6-1397 ) برگشت به فهرست نسخه ها
Caspian Journal of Internal Medicine
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3792