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:: Volume 10, Issue 2 (3-2019) ::
Caspian J Intern Med 2019, 10(2): 125-131 Back to browse issues page
The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency
Maryam Hajhashemi , Maryam Ansari , Fedyeh Haghollahi * , Bita Eslami
Vali ASR Reproductive Health Research Center, Tehran University of Medical Sciences, Tehran, Iran , fedyeh_hagh@yahoo.com
Abstract:   (741 Views)
Background: Uterine leiomyomas (fibroids) are the most common benign pelvic tumors in women of reproductive age with an incidence ranging from 5.4% to 77%, Also, there is a high prevalence of vit D deficiency in Iran and there are the numbers of in vivo and vitro biological studies on the relationship of vitamin D and uterine leiomyomas. The aim of this study was to evaluate the effect of vit D supplementation on the size of uterine leiomyoma in women with vit D deficiency.
Methods: This double-blind prospective clinical trial was performed on 69 patients with uterine leiomyomas who had vit D deficiency. Group A (n=35) was treated with vit D 50,000 IU every 2 weeks for 10 weeks, while group B (n=34) received placebo with same color and shape. Finally, the leiomyoma size in both groups was compared (IRCT: 20160521027998N5).
Results: After a 10-week intervention, 25-hydroxyvitamin D3 levels were significantly higher in group receiving vitamin D (36.08 vs 16.25 ng/ml). (P<0.001) Leiomyomas size in vit D group significantly decreased as compared to placebo group (52.58 vs 61.11 mm, respectively).
Conclusion: Our results showed that administration of vit D3 may reduce the size of leiomyoma. It seems that vitamin D administration is the effective way to treat leiomyoma.
Keywords: Uterine leiomyomas, 25-hydroxyvitamin D3, vitamin D deficiency
Full-Text [PDF 380 kb]   (141 Downloads)    
Type of Study: Original Article | Subject: Obstetrics & Gynicology
Received: 2018/06/10 | Accepted: 2018/10/14 | Published: 2019/05/13
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Hajhashemi M, Ansari M, Haghollahi F, Eslami B. The effect of vitamin D supplementation on the size of uterine leiomyoma in women with vitamin D deficiency. Caspian J Intern Med. 2019; 10 (2) :125-131
URL: http://caspjim.com/article-1-1514-en.html


Volume 10, Issue 2 (3-2019) Back to browse issues page
Caspian Journal of Internal Medicine
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