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:: دوره 10، شماره 4 - ( 6-1398 ) ::
جلد 10 شماره 4 صفحات 424-430 برگشت به فهرست نسخه ها
Factors predicting good outcome of intravenous thrombolysis in stroke patients before rt-PA administration
چکیده:   (261 مشاهده)
Background: To determine whether it is possible to predict intravenous thrombolytic therapy (IVT) outcome after 3 months in acute ischemic stroke patients who are candidate to receive recombinant tissue plasminogen activator (rt-PA), before rt-PA administration based on their risk factors and some available laboratory results.
Methods: We enrolled 118 ischemic stroke patients who were treated with standard dose of Alteplase in our hospital. Baseline characteristics, door-to-needle time (DTN), onset-to-treatment time (OTT), the National Institute Health Stroke Scale (NIHSS), systolic and diastolic blood pressure on admission, history of diabetes, hypertension, dyslipidemia, coronary artery disease (CAD), previous ischemic stroke, atrial fibrillation (AF), laboratory results were retrospectively collected. The modified Rankin Scale (mRS) was recorded after 3 months of admission and patients were divided into good (mRS£ 2) and poor (mRS>2) outcome groups. Chi-square test and t-test were used for categorical and continuous variables, respectively. Predictors for outcome after 3 months were studied by multivariable logistic regression.
Results: Good outcome was seen in 60 (51%) patients and poor outcome was seen in 58 (49%) patients. Significant predictors for outcome at 3 months according to multivariable regression analysis were NIHSS score (odds ratio [OR], 0.61; 95% confidence interval [CI], 0.498-0.750; p<0.001), SBP (OR, 0.95; 95% CI, 0.925-0.991; P=0.01), AF (OR, 0.09; 95% CI, 0.013- 0.708; P=0.02), CAD (OR, 17.08; 95% CI, 0.013-0.708; p=0.003).
Conclusion: Higher NIHSS score, higher SBP on admission, AF and history of CAD could be the independent predictors of outcome after IVT in acute ischemic stroke patients.
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نوع مطالعه: Original Article | موضوع مقاله: Neurology
دریافت: ۱۳۹۷/۶/۲۹ | پذیرش: ۱۳۹۸/۴/۵ | انتشار: ۱۳۹۸/۷/۳
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Mehrpour M, Afrakhteh M, Shojaei S F, Sohrabi A, Ashayeri R, Esmaeili S et al . Factors predicting good outcome of intravenous thrombolysis in stroke patients before rt-PA administration. Caspian J Intern Med. 2019; 10 (4) :424-430
URL: http://caspjim.com/article-1-1610-fa.html

Factors predicting good outcome of intravenous thrombolysis in stroke patients before rt-PA administration. 1. 1398; 10 (4) :424-430

URL: http://caspjim.com/article-1-1610-fa.html



دوره 10، شماره 4 - ( 6-1398 ) برگشت به فهرست نسخه ها
Caspian Journal of Internal Medicine
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