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Creutzfeldt-Jakob disease: A case report
Razieh Salehian , Farzad Sina , Sussan Moudi
Social Determinants of Health Reseach Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran , sussan.mouodi@gmail.com
Abstract:   (357 Views)
Background: Creutzfeldt-Jakob disease (CJD) as a life-threatening neurodegenerative disorder is not usually diagnosed in early stages of the disease, because of a variety in its clinical manifestations. This study aimed to present a middle-aged women with psychiatric symptoms who ultimately was diagnosed as a CJD case.
Case Presentation: This 48-year old woman had progressive symptoms of depressed mood, decreased sleep and appetite and mutism which had been started two months before the first visit. Gradually, slowness in movements, dysarthria and decreased performance were observed. Subsequently,   when antidepressant and antipsychotic drugs were prescribed other symptoms such as ataxia and rigidity manifested in the patient.   
Conclusion: The problem list which led to final confirmation of the disease included non-specific neuropsychological presentations, hypersignality in caudate and putamen areas in brain MRI, generalized high frequency sharp waves in EEG, and protein 14-3-3 identification in cerebrospinal fluid.
Keywords: Creutzfeldt-Jakob Disease, Cognitive Decline, Neurodegenerative Disorders
     
Type of Study: case report | Subject: Neurology
Received: 2019/04/16 | Accepted: 2019/07/30 | Published: 2017/07/15
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Caspian Journal of Internal Medicine
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