:: Volume 11, Issue 3 (5-2020) ::
Caspian J Intern Med 2020, 11(3): 267-277 Back to browse issues page
The relationship between serum 25-hydroxy vitamin D and blood pressure and quality of life in overweight and obese patients with type 2 diabetes mellitus compared with healthy subjects
Naser Aghamohammadzadeh , Neda Dolatkhah , Maryam Hashemian , Seyed Kazem Shakouri , Saeed Hasanpour
Physical Medicine and Rehabilitation Research Center, Aging Research Institute, Tabriz University of Medical Sciences, Tabriz, Iran , neda_dolatkhah@yahoo.com
Abstract:   (283 Views)
Background: Vitamin D is one of the known lipoprotein hormones with metabolic properties. We aimed to determine the serum 25-hydroxy vitamin D concentration in overweight/obese subjects with diabetes mellitus type Ⅱ (DM Ⅱ) in association with systolic and diastolic blood pressure and quality of life compared with healthy participants.
Methods: The current case-control study was carried out among 80 overweight/obese subjects with DM Ⅱ, and 77 healthy subjects matched by sex, age and body mass index (BMI). Serum 25-hydroxyvitamin D concentration was measured by ELISA method. In order to examine the quality of life, the Persian version of SF36 questionnaire was used.                   
Results: There was significant difference between diabetic and healthy subjects considering serum 25-hydroxyvitamin D concentration (p-value = 0.012). Serum 25-hydroxyvitamin D concentration was inversely correlated with diastolic blood pressure (p-value = 0.02) and positively associated with physical function (p-value <0.001), social function (p-value <0.001) and general health (p-value <0.001) components of quality of life in diabetic subjects and physical health sub-scale (p-value = 0.004) in all participants.
Conclusion: Serum 25-hydroxyvitamin D concentration was significantly lower in diabetic subjects in comparison with healthy controls. There was a significant reverse relationship between serum concentrations of 25-hydroxyvitamin D with diastolic blood pressure and on the other hand, a significant positive relationship with physical function, social function and general health components and physical health subscale of quality of life in participants with DM Ⅱ.
Keywords: 25-hydroxy vitamin D, diabetes mellitus, Blood pressure, quality of life
Full-Text [PDF 442 kb]   (13 Downloads)    
Type of Study: Original Article | Subject: Endocrinology
Received: 2019/05/24 | Accepted: 2020/01/21 | Published: 2020/05/21



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Volume 11, Issue 3 (5-2020) Back to browse issues page