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:: Volume 11, Issue 3 (5-2020) ::
Caspian J Intern Med 2020, 11(3): 8-0 Back to browse issues page
Association between pre-chemotherapy serum levels of vitamin D and clinicopathologic findings in gastric cancer
Akbar Hedayatizadeh-Omran , Ghasem Janbabaei , Reza Alizadeh-Navaei , Omolbanin Amjadi , Jeyran Mahdavi Izadi , Versa Omrani-Nava
Gastrointestinal cancer research center, Mazandaran University of Medical Sciences, Sari, Iran. , versa.peace@gmail.com
Abstract:   (257 Views)
Background: To examine serum levels of vitamin D in newly diagnosed gastric cancer (GC) patients compared with normal subjects and any possible association with prognostic variables.
Methods: One-hundred subjects (50 GC and 50 controls) were enrolled and serum vitamin D levels were assessed using ELISA. Based on two definitions, vitamin D was classified as a sufficient level (≥30 ng/dL) and optimal level (25-80 ng/dL). The χ2and unpaired t-test was used for data analysis with a significance level of 0.05.
Results: The mean serum levels of vitamin D in patients and controls were 26.86 (±14.6) and 31.72 (±13.4), respectively (P=0.09). The prevalence of vitamin D insufficiency and deficiency was higher in GC cases than controls (P=0.045 if sufficient level ≥30 and P=0.065 if sufficient level ≥25). According to histological grade analysis, grade 3 patients (poorly differentiated) were found with significantly lower vitamin D concentrations in serum than grade 1 and 2 subjects (22.25 vs 33.29 ng/dL, P=0.021).  No significant differences were observed between the two groups in Pathological tumor-node-metastasis(pTNM) stages, distant metastasis, and location of the tumor.
Conclusion: Higher prevalence of vitamin D insufficiency and deficiency in GC patients may reflect its role in malignancy; however, further studies are needed to confirm this relationship and any possible benefitsto the patients.
Keywords: Gastric cancer, vitamin D, ELISA
     
Type of Study: Original Article | Subject: Oncology
Received: 2019/07/9 | Accepted: 2019/12/3 | Published: 2020/05/21
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Hedayatizadeh-Omran A, Janbabaei G, Alizadeh-Navaei R, Amjadi O, Mahdavi Izadi J, Omrani-Nava V. Association between pre-chemotherapy serum levels of vitamin D and clinicopathologic findings in gastric cancer. Caspian J Intern Med. 2020; 11 (3) :8-0
URL: http://caspjim.com/article-1-1973-en.html


Volume 11, Issue 3 (5-2020) Back to browse issues page
Caspian Journal of Internal Medicine
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