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:: Volume 13, Issue 4 (Autumn 2022) ::
Caspian J Intern Med 2022, 13(4): 818-826 Back to browse issues page
A pure Cutaneous Rosai-Dorfman disease: case report and a review of the literature
Fatemeh Montazer , Saeedeh Farahani , Zoha Shaka , Zeinab Aryanian , Azadeh Goodarzi *
Department of Dermatology, Rasool Akram Medical Complex, Iran University of Medical Sciences, Tehran, Iran , azadeh_goodarzi1984@yahoo.com
Abstract:   (1394 Views)
Background: Cutaneous Rosai-Dorfman disease (CRDD) is a rare variant of benign histiocytic proliferative disorder limited to the skin. The underlying etiology is still unclear, but it had been claimed that infections, immunodeficiencies, and autoimmune disorders might have a role in the etiology of this disorder. The characteristic presentation of RDD is lymphadenopathy due to abnormal production and accumulation of histiocytes in lymph nodes; however, the extra-nodal areas could also be affected, such as cutaneous. Herein, we presented a 45-year-old Iranian woman presented with an atypical pure cutaneous Rosai Dorfman disease, in addition to a summarized list of atypical cases of RDD that are reported as pure cutaneous RDD with atypical presentation.
Case presentation:  Herein, we presented a 45-year-old woman who referred to us with an ulcerative nodule with a size of 5×5 cm on her buttock, gradually growing over one year. After the primary evaluations, a biopsy specimen was obtained, and histologic studies revealed a dense cellular infiltrate involving the dermis and the subcutis, which was composed of abundant sheets of large histiocytes with admixtures of lymphocytes, plasma cells, neutrophils, and eosinophils within their cytoplasm -known as the emperipolesis phenomenon. The immunohistochemistry staining was positive for S100 and CD68 and negative for CD1a.
Conclusion: The diagnosis of CRDD was confirmed based on these histopathological findings.

Keywords: pure cutaneous Rosai Dorfman disease, histiocytosis, atypical cutaneous presentation, non-Langerhans cell histiocytosis, review, case report, histopathology
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Type of Study: Review Article | Subject: Dermathology
Received: 2021/05/29 | Accepted: 2021/11/16 | Published: 2022/09/2
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Montazer F, Farahani S, Shaka Z, Aryanian Z, Goodarzi A. A pure Cutaneous Rosai-Dorfman disease: case report and a review of the literature. Caspian J Intern Med 2022; 13 (4) :818-826
URL: http://caspjim.com/article-1-2932-en.html

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Volume 13, Issue 4 (Autumn 2022) Back to browse issues page
Caspian Journal of Internal Medicine
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