[Home ] [Archive]    
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 9, Issue 2 (1-2018) ::
Caspian J Intern Med 2018, 9(2): 116-120 Back to browse issues page
Paraoxonase Activities in Metabolic Syndrome in Children and Adolescents
Arati Adhe-Rojekar , Mukund Ramchandra Mogarekar , Mohit Vijay Rojekar
Dept of Biochemistry Rajiv Gandhi Medical College, Thane, India , drmohi44@gmail.com
Abstract:   (1959 Views)
Background: Metabolic syndrome (MetS) is a collection of various interrelated risk factors that appear to have an impact as development of atherosclerotic cardiovascular disease (CVDs). Epidemic of childhood and adolescent’s obesity has increased interest in the metabolic syndrome (MS) due to the potential projection into adulthood. The prevalence of MS in adolescents has been estimated to be 6.7% in young adults and 4.2% in adolescents. We aimed to study the MetS in children and adolescents with respect to metabolic changes.
Methods: The international Diabetes Federation criteria were used for the selection of cases. Serum paraoxonase 1 (PON1) activities were measured using spectrophotometer. Statistical analysis was done using MyStat statistical software.
Results: Serum PON1 arylesterase (ARE) and lactonase (LACT) activities were found to be reduced significantly in patients with MetS than in controls. Regression analysis showed a significant correlation between PON1 activities and body mass index. Area under curve (AUC) found to increase from HDL to PON1 ARE to PON1 LACT.
Conclusions: From the present study, it is clear that in children and adolescents, reduction in PON1 activities in MetS is mainly due either to abnormalities with synthesis or secretion of HDL cholesterol or oxidative stress as a consequence of excess production of the free radicals. This study also iterates that it is the quality and not the quantity of HDL cholesterol which is important while studying the pathophysiology of MetS.

Keywords: Paraoxonase1, Arylesterase, Lactonase, Area under Curve, ROC curve, Regression Analysis
Full-Text [PDF 233 kb]   (278 Downloads)    
Type of Study: Original Article | Subject: Endocrinology
Received: 2015/07/31 | Accepted: 2017/11/1 | Published: 2018/01/8
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Adhe-Rojekar A, Ramchandra Mogarekar M, Vijay Rojekar M. Paraoxonase Activities in Metabolic Syndrome in Children and Adolescents. Caspian J Intern Med. 2018; 9 (2) :116-120
URL: http://caspjim.com/article-1-590-en.html


Volume 9, Issue 2 (1-2018) Back to browse issues page
Caspian Journal of Internal Medicine
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3764