Abbasali Ahmadi, Parviz Amri, Javad Shokri-Shirvani, Karimollah Hajian,
Volume 6, Issue 2 (4-2015)
Background: Although some patients can tolerate
colonoscopy procedure using fentanyl/ midazolam without any sedation and
analgesic requirements but some patients may require additional sedation with
benzodiazepines. We performed the present study to compare the effect of
paracetamol/midazolam with fentanyl/ midazolam.
Methods: In a clinical trial, 96 patients aged 18
to 75 years old, who were candidate for elective colonoscopy assigned
consecutively into two groups as paracetamol/midazolam and fentanyl/midazolam.
The first group received 1 gr paracetamol 45 minutes before colonoscopy and 0.5
mg/kg midazolam 5 minutes before colonoscopy whereas the second group received 04-
0.5-1 mcg/kg fentanyl 3 minutes before colonoscopy and similar dose of
midazolam. The two groups were compared in regard to patient intensity,
discomfort, a colonoscopist and, patient satisfaction and rescue dose
of propofol during colonoscopy and vital signs.
Results: There was no significant difference
between the two groups for patient pain score, colonoscopist satisfaction,
patient satisfaction and rescue dose of propofol (P=0.817, 0.978, 0.460, and 0.104, respectively). The incidence
of apnea was greater in fentanyl group (P=0.045). After adjusting for age and
education, there was also no significant difference between the two groups.
Conclusion: This study indicates that paracetamol can
be considered as an alternative drug regimen in preparation of colonoscopy.
