Mehrdad Kashifard, Ebrahim Alijanpour, Mohammad Hoseinian, Pouya Tayebi,
Volume 1, Issue 3 (1-2010)
Abstract
Background: Halothane is the routine used inhalation anesthetic drug in the world but at present, there is an increasing interest for using intravenous anesthetics like propofol. The purpose of this study was to compare these anesthetic effects on hepatic enzymes.
Methods: From 2006 to 2007, this study was performed on fifty eight patients classified in class I of American Society of Anesthetics. These patients had no preliminary symptomatic hepatic, cardiac or renal disease admitted for elective surgery in Yahyahnejiad Hospital, Babol University of Medical Sciences. These patients were divided randomly into two groups. Thirty patients in the study group (Propofol) and twenty eight patients in the control group (Halothane). In both groups, pre-meditation and induction of anesthesia were the same. For the maintenance of anesthesia in the study group there was continuous infusion of propofol and for the control group, 0.5-1% halothane inhalation. From all the patients, we got three blood samples separately prior to the anesthesia, twenty four hours and seven days after the anesthesia. These samples were tested for aspartate aminotransferase (AST), alanine amino transferase (ALT), alkaline phosphates (ALP) and Billirubin (total and direct).
Results: Seven days after anesthesia ALP, the total and direct Billirubin levels did not have differences between the two groups. However, AST (p=0.008) and ALT (p=0.003) increased in halothane group in compared with propofol group.
Conclusion: The results show that propofol has less effect on liver enzymes as compared to halothane.
Mohammad Taghi Ashoobi, Farahnaz Joukar, Kourosh Mojtahedi, Saman Maroufizadeh, Mohammadreza Javid, Ali Parvaneh, Tahereh Zeinali, Niloofar Faraji, Mohammadreza Naghipour, Fariborz Mansour-Ghanaei,
Volume 16, Issue 1 (1-2025)
Abstract
Background: Diabetes mellitus (DM) is highly consequential to global health among chronic diseases. Due to a limited researches that have examined relationships between liver enzymes and DM, this study aimed to investigate the link between elevated liver enzymes and diabetes among Prospective Epidemiological Research Studies in Iran (PERSIAN) Guilan cohort study (PGCS) population.
Methods: This cross-sectional study was conducted on 10519 individuals. The demographic and clinical information of the participants was recorded. The changes in alanine aminotransferases (ALT) and aspartate aminotransferases (AST), alkaline phosphatase (ALP), and γ-glutamyltransferase (GGT) were evaluated. IBM SPSS Version 21 was used to analyze the data, with a significance level < 0.05.
Results: The frequency of diabetes was 24.1% and was more prevalent in women than men (27.4% vs. 20.2%, p< 0.001). After removing all confederates, patients with elevated ALT, AST, GGT, and ALP levels were 1.27, 1.27, 1.52, and 1.46 times more likely to have diabetes, respectively. The likelihood of developing diabetes rose in correlation with the number of elevated liver enzymes, up to almost 1.77-fold among subjects with three or four increased liver enzymes.
Conclusion: Patients diagnosed with diabetes exhibited significantly increased levels of liver enzymes compared to those without diabetes. Also, impairment of three or four liver enzymes demonstrated a positive correlation with an elevated likelihood of DM. This indicates the importance of considering the liver status in the management of the DM population.
